Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb

T. S. Rosenkrantz, I. Knox, E. L. Zalneraitis, J. R. Raye, P. J. Porte, R. Cramer, R. Smoloski, Anthony F Philipps

Research output: Contribution to journalArticle

Abstract

Previous studies in the fetal lamb have demonstrated that hyperglycemia stimulates the fetal metabolic rate. The present study examined the effects of chronic fetal hyperglycemia on fetal cerebral metabolic rate and electrocortical activity. Nine chronically instrumented fetal lambs had measurements of cerebral blood flow and cerebral uptake/excretion of oxygen, glucose, lactate, and β-hydroxybutyrate taken before and during a 48-h fetal glucose infusion. Electrocortical activity was also recorded. The fetal arterial glucose concentration was 19.8 ± 2.0 mg/dl before glucose infusion and 48 ± 4.5 to 54.6 ± 6.6 mg/dl during the infusion period. Cerebral blood flow and cerebral glucose and oxygen uptake increased by 219, 209, and 171%, respectively, by the end of the infusion period. There was a linear relationship between the fetal arterial glucose concentration and cerebral blood flow and cerebral glucose and oxygen uptakes. The electroencephalogram showed significant slowing with increases in the cerebral metabolic rate. These findings suggest that fetal hyperglycemia is associated with significant metabolic stimulation of the brain.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume265
Issue number6 34-6
StatePublished - 1993
Externally publishedYes

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Cerebrovascular Circulation
Glucose
Hyperglycemia
Oxygen
Hydroxybutyrates
Electroencephalography
Lactic Acid
Brain

Keywords

  • cerebral glucose transport
  • cerebral glucose-oxygen quotient
  • diabetes
  • infant of a diabetic mother
  • insulin
  • metabolism
  • microspheres
  • regulation
  • sheep

ASJC Scopus subject areas

  • Physiology

Cite this

Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb. / Rosenkrantz, T. S.; Knox, I.; Zalneraitis, E. L.; Raye, J. R.; Porte, P. J.; Cramer, R.; Smoloski, R.; Philipps, Anthony F.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 265, No. 6 34-6, 1993.

Research output: Contribution to journalArticle

Rosenkrantz, T. S. ; Knox, I. ; Zalneraitis, E. L. ; Raye, J. R. ; Porte, P. J. ; Cramer, R. ; Smoloski, R. ; Philipps, Anthony F. / Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1993 ; Vol. 265, No. 6 34-6.
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AU - Porte, P. J.

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