Cerebral ischemia-reperfusion injury after severe head injury and its possible treatment with polyethyleneglycol-superoxide dismutase

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Abstract

Oxygen radical-mediated mechanisms play a role both in cerebral ischemia-reperfusion injury and in traumatic brain injury. Moreover, my work with measurements of cerebral blood flow with the 133Xe method and the stable xenon-computed tomography method and through measurements of arteriovenous difference of oxygen indicates that ischemia and ischemia-reperfusion are also part of traumatic brain injury but only in the first few hours after injury. The contributions of the research laboratories at the Medical College of Virginia, Richmond, to the understanding of the role of oxygen free radicals in traumatic brain injury are discussed. Finally, a trial of the oxygen radical scavenger polyethyleneglycol-superoxide dismutase in human beings with severe head injuries shows that death and vegetative state occurred twice as often in the 26 patients receiving placebo compared with the group of 26 patients receiving a 10,000 U/kg bolus of polyethyleneglycol-superoxide dismutase (43%, respectively; 20% at three months; P < .03).

Original languageEnglish (US)
Pages (from-to)1014
Number of pages1
JournalAnnals of Emergency Medicine
Volume22
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Reperfusion Injury
Brain Ischemia
Craniocerebral Trauma
Superoxide Dismutase
Reactive Oxygen Species
Cerebrovascular Circulation
Ischemia
Persistent Vegetative State
Xenon
Reperfusion
Free Radicals
Therapeutics
Tomography
Placebos
Oxygen
Wounds and Injuries
Research
Traumatic Brain Injury

Keywords

  • brain injury
  • ischemia-reperfusion

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

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abstract = "Oxygen radical-mediated mechanisms play a role both in cerebral ischemia-reperfusion injury and in traumatic brain injury. Moreover, my work with measurements of cerebral blood flow with the 133Xe method and the stable xenon-computed tomography method and through measurements of arteriovenous difference of oxygen indicates that ischemia and ischemia-reperfusion are also part of traumatic brain injury but only in the first few hours after injury. The contributions of the research laboratories at the Medical College of Virginia, Richmond, to the understanding of the role of oxygen free radicals in traumatic brain injury are discussed. Finally, a trial of the oxygen radical scavenger polyethyleneglycol-superoxide dismutase in human beings with severe head injuries shows that death and vegetative state occurred twice as often in the 26 patients receiving placebo compared with the group of 26 patients receiving a 10,000 U/kg bolus of polyethyleneglycol-superoxide dismutase (43{\%}, respectively; 20{\%} at three months; P < .03).",
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