Cerebral hyperemia measured with near infrared spectroscopy during treatment of diabetic ketoacidosis in children

Nicole Glaser, Daniel J Tancredi, James P Marcin, Ryan Caltagirone, Yvonne Lee, Christopher Murphy, Nathan Kuppermann

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective To use near infrared spectroscopy (NIRS) to evaluate the timing of onset and duration of cerebral hyperemia during diabetic ketoacidosis (DKA) treatment in children, and to investigate the relationship of cerebral hyperemia to intravenous fluid treatment. Study design We randomized children aged 8-18 years with DKA to either more rapid or slower intravenous fluid treatment (19 total DKA episodes). NIRS was used to measure rSo2 during DKA treatment. NIRS monitoring began as soon as informed consent was obtained and continued until the patient was transferred out of the critical care unit. Results rSo2 values above the normal range (>80%) were detected in 17 of 19 DKA episodes (mean rSo2 during initial 8 hours of DKA treatment: 86% ± 7%, range 65%-95%). Elevated rSo2 values were detected as early as the second hour of DKA treatment and persisted for as long as 27 hours. Hourly mean rSo2 levels during treatment did not differ significantly by fluid treatment group. Conclusions During DKA treatment, children have elevated rSo2 values consistent with cerebral hyperemia. Hyperemia occurs as early as the second hour of DKA treatment and may persist for ≥27 hours. Cerebral rSo2 levels during treatment did not differ significantly in patients treated with slower versus more rapid intravenous rehydration.

Original languageEnglish (US)
Pages (from-to)1111-1116
Number of pages6
JournalJournal of Pediatrics
Volume163
Issue number4
DOIs
StatePublished - Oct 2013

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Diabetic Ketoacidosis
Near-Infrared Spectroscopy
Hyperemia
Therapeutics
Fluid Therapy
Critical Care
Informed Consent
Reference Values

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cerebral hyperemia measured with near infrared spectroscopy during treatment of diabetic ketoacidosis in children. / Glaser, Nicole; Tancredi, Daniel J; Marcin, James P; Caltagirone, Ryan; Lee, Yvonne; Murphy, Christopher; Kuppermann, Nathan.

In: Journal of Pediatrics, Vol. 163, No. 4, 10.2013, p. 1111-1116.

Research output: Contribution to journalArticle

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abstract = "Objective To use near infrared spectroscopy (NIRS) to evaluate the timing of onset and duration of cerebral hyperemia during diabetic ketoacidosis (DKA) treatment in children, and to investigate the relationship of cerebral hyperemia to intravenous fluid treatment. Study design We randomized children aged 8-18 years with DKA to either more rapid or slower intravenous fluid treatment (19 total DKA episodes). NIRS was used to measure rSo2 during DKA treatment. NIRS monitoring began as soon as informed consent was obtained and continued until the patient was transferred out of the critical care unit. Results rSo2 values above the normal range (>80{\%}) were detected in 17 of 19 DKA episodes (mean rSo2 during initial 8 hours of DKA treatment: 86{\%} ± 7{\%}, range 65{\%}-95{\%}). Elevated rSo2 values were detected as early as the second hour of DKA treatment and persisted for as long as 27 hours. Hourly mean rSo2 levels during treatment did not differ significantly by fluid treatment group. Conclusions During DKA treatment, children have elevated rSo2 values consistent with cerebral hyperemia. Hyperemia occurs as early as the second hour of DKA treatment and may persist for ≥27 hours. Cerebral rSo2 levels during treatment did not differ significantly in patients treated with slower versus more rapid intravenous rehydration.",
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T1 - Cerebral hyperemia measured with near infrared spectroscopy during treatment of diabetic ketoacidosis in children

AU - Glaser, Nicole

AU - Tancredi, Daniel J

AU - Marcin, James P

AU - Caltagirone, Ryan

AU - Lee, Yvonne

AU - Murphy, Christopher

AU - Kuppermann, Nathan

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N2 - Objective To use near infrared spectroscopy (NIRS) to evaluate the timing of onset and duration of cerebral hyperemia during diabetic ketoacidosis (DKA) treatment in children, and to investigate the relationship of cerebral hyperemia to intravenous fluid treatment. Study design We randomized children aged 8-18 years with DKA to either more rapid or slower intravenous fluid treatment (19 total DKA episodes). NIRS was used to measure rSo2 during DKA treatment. NIRS monitoring began as soon as informed consent was obtained and continued until the patient was transferred out of the critical care unit. Results rSo2 values above the normal range (>80%) were detected in 17 of 19 DKA episodes (mean rSo2 during initial 8 hours of DKA treatment: 86% ± 7%, range 65%-95%). Elevated rSo2 values were detected as early as the second hour of DKA treatment and persisted for as long as 27 hours. Hourly mean rSo2 levels during treatment did not differ significantly by fluid treatment group. Conclusions During DKA treatment, children have elevated rSo2 values consistent with cerebral hyperemia. Hyperemia occurs as early as the second hour of DKA treatment and may persist for ≥27 hours. Cerebral rSo2 levels during treatment did not differ significantly in patients treated with slower versus more rapid intravenous rehydration.

AB - Objective To use near infrared spectroscopy (NIRS) to evaluate the timing of onset and duration of cerebral hyperemia during diabetic ketoacidosis (DKA) treatment in children, and to investigate the relationship of cerebral hyperemia to intravenous fluid treatment. Study design We randomized children aged 8-18 years with DKA to either more rapid or slower intravenous fluid treatment (19 total DKA episodes). NIRS was used to measure rSo2 during DKA treatment. NIRS monitoring began as soon as informed consent was obtained and continued until the patient was transferred out of the critical care unit. Results rSo2 values above the normal range (>80%) were detected in 17 of 19 DKA episodes (mean rSo2 during initial 8 hours of DKA treatment: 86% ± 7%, range 65%-95%). Elevated rSo2 values were detected as early as the second hour of DKA treatment and persisted for as long as 27 hours. Hourly mean rSo2 levels during treatment did not differ significantly by fluid treatment group. Conclusions During DKA treatment, children have elevated rSo2 values consistent with cerebral hyperemia. Hyperemia occurs as early as the second hour of DKA treatment and may persist for ≥27 hours. Cerebral rSo2 levels during treatment did not differ significantly in patients treated with slower versus more rapid intravenous rehydration.

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