Abstract
Positron emission tomography and the glucose metabolic tracer [18F]fluorodeoxyglucose were used to evaluate the relationship between regional cerebral metabolic rates for glucose (rCMRglc), age, and performance on a delayed response (DR) test of memory in the aged monkey. Eleven aged animals, 21-26-years old, were included in the analysis. Regional CMRglc, normalized to values for the entire brain, were determined for the dorsal prefrontal cortex, orbitofrontal cortex, hippocampus, and temporal cortex. The aged animals exhibited significant DR deficits relative to a cohort of normal young monkeys. Variability in DR performance among the aged subjects was significantly correlated with relative hippocampal rCMRglc, and chronological age was a reliable predictor of orbitofrontal rCMRglc ratios. This pattern of results suggests that DR impairments in the aged monkey may partly reflect age-related dysfunction distributed among multiple limbic system structures that participate in normal learning and memory. Overall, the findings support the use of positron emission tomography in efforts to define the relationship between cognitive performance, age, and brain physiology in nonhuman primates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 437-443 |
| Number of pages | 7 |
| Journal | Neurobiology of Aging |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1997 |
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Keywords
- Aging Rhesus macaques
- Delayed response
- Glucose metabolism
- Hippocampus
- Memory
- Monkey
- Orbitofrontal cortex
- PET
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
Cerebral glucose metabolism and memory in aged rhesus macaques. / Eberling, J. L.; Roberts, Jeffrey A; Rapp, P. R.; Tuszynski, M. H.; Jagust, W. J.
In: Neurobiology of Aging, Vol. 18, No. 4, 07.1997, p. 437-443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral glucose metabolism and memory in aged rhesus macaques
AU - Eberling, J. L.
AU - Roberts, Jeffrey A
AU - Rapp, P. R.
AU - Tuszynski, M. H.
AU - Jagust, W. J.
PY - 1997/7
Y1 - 1997/7
N2 - Positron emission tomography and the glucose metabolic tracer [18F]fluorodeoxyglucose were used to evaluate the relationship between regional cerebral metabolic rates for glucose (rCMRglc), age, and performance on a delayed response (DR) test of memory in the aged monkey. Eleven aged animals, 21-26-years old, were included in the analysis. Regional CMRglc, normalized to values for the entire brain, were determined for the dorsal prefrontal cortex, orbitofrontal cortex, hippocampus, and temporal cortex. The aged animals exhibited significant DR deficits relative to a cohort of normal young monkeys. Variability in DR performance among the aged subjects was significantly correlated with relative hippocampal rCMRglc, and chronological age was a reliable predictor of orbitofrontal rCMRglc ratios. This pattern of results suggests that DR impairments in the aged monkey may partly reflect age-related dysfunction distributed among multiple limbic system structures that participate in normal learning and memory. Overall, the findings support the use of positron emission tomography in efforts to define the relationship between cognitive performance, age, and brain physiology in nonhuman primates.
AB - Positron emission tomography and the glucose metabolic tracer [18F]fluorodeoxyglucose were used to evaluate the relationship between regional cerebral metabolic rates for glucose (rCMRglc), age, and performance on a delayed response (DR) test of memory in the aged monkey. Eleven aged animals, 21-26-years old, were included in the analysis. Regional CMRglc, normalized to values for the entire brain, were determined for the dorsal prefrontal cortex, orbitofrontal cortex, hippocampus, and temporal cortex. The aged animals exhibited significant DR deficits relative to a cohort of normal young monkeys. Variability in DR performance among the aged subjects was significantly correlated with relative hippocampal rCMRglc, and chronological age was a reliable predictor of orbitofrontal rCMRglc ratios. This pattern of results suggests that DR impairments in the aged monkey may partly reflect age-related dysfunction distributed among multiple limbic system structures that participate in normal learning and memory. Overall, the findings support the use of positron emission tomography in efforts to define the relationship between cognitive performance, age, and brain physiology in nonhuman primates.
KW - Aging Rhesus macaques
KW - Delayed response
KW - Glucose metabolism
KW - Hippocampus
KW - Memory
KW - Monkey
KW - Orbitofrontal cortex
KW - PET
UR - http://www.scopus.com/inward/record.url?scp=0030866387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030866387&partnerID=8YFLogxK
U2 - 10.1016/S0197-4580(97)00040-7
DO - 10.1016/S0197-4580(97)00040-7
M3 - Article
C2 - 9330976
AN - SCOPUS:0030866387
VL - 18
SP - 437
EP - 443
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 4
ER -