Cerebral glucose metabolism and memory in aged rhesus macaques

J. L. Eberling, Jeffrey A Roberts, P. R. Rapp, M. H. Tuszynski, W. J. Jagust

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Positron emission tomography and the glucose metabolic tracer [18F]fluorodeoxyglucose were used to evaluate the relationship between regional cerebral metabolic rates for glucose (rCMRglc), age, and performance on a delayed response (DR) test of memory in the aged monkey. Eleven aged animals, 21-26-years old, were included in the analysis. Regional CMRglc, normalized to values for the entire brain, were determined for the dorsal prefrontal cortex, orbitofrontal cortex, hippocampus, and temporal cortex. The aged animals exhibited significant DR deficits relative to a cohort of normal young monkeys. Variability in DR performance among the aged subjects was significantly correlated with relative hippocampal rCMRglc, and chronological age was a reliable predictor of orbitofrontal rCMRglc ratios. This pattern of results suggests that DR impairments in the aged monkey may partly reflect age-related dysfunction distributed among multiple limbic system structures that participate in normal learning and memory. Overall, the findings support the use of positron emission tomography in efforts to define the relationship between cognitive performance, age, and brain physiology in nonhuman primates.

Original languageEnglish (US)
Pages (from-to)437-443
Number of pages7
JournalNeurobiology of Aging
Volume18
Issue number4
DOIs
StatePublished - Jul 1997

Fingerprint

Macaca mulatta
Haplorhini
Glucose
Prefrontal Cortex
Positron-Emission Tomography
Limbic System
Fluorodeoxyglucose F18
Brain
Temporal Lobe
Primates
Hippocampus
Learning

Keywords

  • Aging Rhesus macaques
  • Delayed response
  • Glucose metabolism
  • Hippocampus
  • Memory
  • Monkey
  • Orbitofrontal cortex
  • PET

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Cerebral glucose metabolism and memory in aged rhesus macaques. / Eberling, J. L.; Roberts, Jeffrey A; Rapp, P. R.; Tuszynski, M. H.; Jagust, W. J.

In: Neurobiology of Aging, Vol. 18, No. 4, 07.1997, p. 437-443.

Research output: Contribution to journalArticle

Eberling, J. L. ; Roberts, Jeffrey A ; Rapp, P. R. ; Tuszynski, M. H. ; Jagust, W. J. / Cerebral glucose metabolism and memory in aged rhesus macaques. In: Neurobiology of Aging. 1997 ; Vol. 18, No. 4. pp. 437-443.
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