Cerebral glucose metabolic differences in patients with panic disorder

Thomas E Nordahl, William E. Semple, Michael Gross, Thomas A. Mellman, Murray B. Stein, Peter Goyer, Anna C. King, Thomas W. Uhde, Robert M. Cohen

Research output: Contribution to journalArticlepeer-review

174 Scopus citations


Regional glucose metabolic rates were measured in patients with panic disorder during the performance of auditory discrimination. Those regions examined by Reiman and colleagues in their blood flow study of panic disorder [Nature 310:683 (1984)] were examined with a higher resolution positron emission tomography (PET) scanner and with the tracer [F-18]-2-fluoro-2-deoxyglucose (FDG). In contrast to the blood flow findings of Reiman et al., we did not find global gray metabolic differences between patients with panic disorder and normal controls. Consistent with the findings of Reiman et al. [Nature; Am J Psychiatry 143:469 (1986)], we found hippocampal region asymmetry. We also found metabolic decreases in the left inferior parietal lobule and in the anterior cingulate (trend), as well as an increase in the metabolic rate of the medial orbital frontal cortex (trend) of panic disorder patients. It is unclear whether the continuous performance task (CPT) enhanced or diminished findings that would have been noted in a study performed without task.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
Issue number4
StatePublished - Aug 1990


  • Anxiety
  • Continuous performance task (CPT)
  • Obsessive compulsive disorder
  • Panic disorder
  • Tomography-emission computed

ASJC Scopus subject areas

  • Pharmacology


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