Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings

H. J. Aronen, I. E. Gazit, D. N. Louis, B. R. Buchbinder, F. S. Pardo, R. M. Weisskoff, G. R. Harsh, G. R. Cosgrove, E. F. Halpern, F. H. Hochberg, B. R. Rosen

Research output: Contribution to journalArticlepeer-review

787 Scopus citations


PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas. MATERIALS AND METHODS: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material. RESULTS: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity. CONCLUSION: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
Issue number1
StatePublished - 1994
Externally publishedYes


  • Brain neoplasms
  • Magnetic resonance (MR), echo planar
  • Magnetic resonance (MR), vascular studies
  • Magnetic resonance (MR), volume measurement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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