Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings

H. J. Aronen; I. E. Gazit; D. N. Louis; B. R. Buchbinder; F. S. Pardo; R. M. Weisskoff; G. R. Harsh; G. R. Cosgrove; E. F. Halpern; F. H. Hochberg; B. R. Rosen

doi:10.1148/radiology.191.1.8134596

Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings

H. J. Aronen, I. E. Gazit, D. N. Louis, B. R. Buchbinder, F. S. Pardo, R. M. Weisskoff, G. R. Harsh, G. R. Cosgrove, E. F. Halpern, F. H. Hochberg, B. R. Rosen

Research output: Contribution to journal › Article › peer-review

768 Scopus citations

Abstract

PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas. MATERIALS AND METHODS: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material. RESULTS: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity. CONCLUSION: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

Original language	English (US)
Pages (from-to)	41-51
Number of pages	11
Journal	RADIOLOGY
Volume	191
Issue number	1
DOIs	https://doi.org/10.1148/radiology.191.1.8134596
State	Published - 1994
Externally published	Yes

Keywords

Brain neoplasms
Magnetic resonance (MR), echo planar
Magnetic resonance (MR), vascular studies
Magnetic resonance (MR), volume measurement

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.191.1.8134596

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Cerebral blood volume maps of gliomas : Comparison with tumor grade and histologic findings. / Aronen, H. J.; Gazit, I. E.; Louis, D. N.; Buchbinder, B. R.; Pardo, F. S.; Weisskoff, R. M.; Harsh, G. R.; Cosgrove, G. R.; Halpern, E. F.; Hochberg, F. H.; Rosen, B. R.

In: RADIOLOGY, Vol. 191, No. 1, 1994, p. 41-51.

Research output: Contribution to journal › Article › peer-review

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title = "Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings",

abstract = "PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas. MATERIALS AND METHODS: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material. RESULTS: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity. CONCLUSION: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.",

keywords = "Brain neoplasms, Magnetic resonance (MR), echo planar, Magnetic resonance (MR), vascular studies, Magnetic resonance (MR), volume measurement",

author = "Aronen, {H. J.} and Gazit, {I. E.} and Louis, {D. N.} and Buchbinder, {B. R.} and Pardo, {F. S.} and Weisskoff, {R. M.} and Harsh, {G. R.} and Cosgrove, {G. R.} and Halpern, {E. F.} and Hochberg, {F. H.} and Rosen, {B. R.}",

year = "1994",

doi = "10.1148/radiology.191.1.8134596",

language = "English (US)",

volume = "191",

pages = "41--51",

journal = "Radiology",

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TY - JOUR

T1 - Cerebral blood volume maps of gliomas

T2 - Comparison with tumor grade and histologic findings

AU - Aronen, H. J.

AU - Gazit, I. E.

AU - Louis, D. N.

AU - Buchbinder, B. R.

AU - Pardo, F. S.

AU - Weisskoff, R. M.

AU - Harsh, G. R.

AU - Cosgrove, G. R.

AU - Halpern, E. F.

AU - Hochberg, F. H.

AU - Rosen, B. R.

PY - 1994

Y1 - 1994

N2 - PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas. MATERIALS AND METHODS: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material. RESULTS: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity. CONCLUSION: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

AB - PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas. MATERIALS AND METHODS: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material. RESULTS: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity. CONCLUSION: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

KW - Brain neoplasms

KW - Magnetic resonance (MR), echo planar

KW - Magnetic resonance (MR), vascular studies

KW - Magnetic resonance (MR), volume measurement

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Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings

Abstract

Keywords

ASJC Scopus subject areas

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