Abstract
CT scanning performed before and sequentially during the inhalation of stable xenon (32%), coupled with end-tidal xenon measurements, has made possible the routine construction of regional cerebral blood flow (rCBF) maps with resolution that approximates that of the CT scanner. The capability of obtaining quantitative flow maps with direct anatomic correlation is now available with a commercial package of hardware and software adapted to the General Electric 9800 scanner. The ability to distinguish between normal and reduced rCBF in specific vascular territories has proved useful in the management of cerebrovascular disease. Specific clinical dilemmas that have been addressed with rCBF information from xenon-enhanced CT scanning include the following: (1) In the patient with asymptomatic occlusive disease, is normal rCBF preserved? Is there adequate collateral flow? (2) Are cerebrovascular symptoms a result of emboli or chronic regional low flow? (3) In the patient with complex multivessel occlusive disease, which revascularization procedure is indicated first? Did operation improve rCBF? Should a further procedure be added? (4) May a diffusely diseased but patent artery, which is the source of emboli, be sacrificed safely without compromising rCBF? On the basis of experience with 155 patients, the management and understanding of cerebrovascular disease has been aided substantially by the incorporation of rCBF mapping by xenon-enhanced CT scan in the evaluation of these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 298-304 |
| Number of pages | 7 |
| Journal | Journal of Vascular Surgery |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Cerebral blood flow measured by xenon-enhanced computed tomography as a guide to management of patients with cerebrovascular disease. / Webster, Marshall W.; Steed, David L.; Yonas, Howard; Latchaw, Richard E; Wolfson, Sidney K.; Gur, David.
In: Journal of Vascular Surgery, Vol. 3, No. 2, 1986, p. 298-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral blood flow measured by xenon-enhanced computed tomography as a guide to management of patients with cerebrovascular disease
AU - Webster, Marshall W.
AU - Steed, David L.
AU - Yonas, Howard
AU - Latchaw, Richard E
AU - Wolfson, Sidney K.
AU - Gur, David
PY - 1986
Y1 - 1986
N2 - CT scanning performed before and sequentially during the inhalation of stable xenon (32%), coupled with end-tidal xenon measurements, has made possible the routine construction of regional cerebral blood flow (rCBF) maps with resolution that approximates that of the CT scanner. The capability of obtaining quantitative flow maps with direct anatomic correlation is now available with a commercial package of hardware and software adapted to the General Electric 9800 scanner. The ability to distinguish between normal and reduced rCBF in specific vascular territories has proved useful in the management of cerebrovascular disease. Specific clinical dilemmas that have been addressed with rCBF information from xenon-enhanced CT scanning include the following: (1) In the patient with asymptomatic occlusive disease, is normal rCBF preserved? Is there adequate collateral flow? (2) Are cerebrovascular symptoms a result of emboli or chronic regional low flow? (3) In the patient with complex multivessel occlusive disease, which revascularization procedure is indicated first? Did operation improve rCBF? Should a further procedure be added? (4) May a diffusely diseased but patent artery, which is the source of emboli, be sacrificed safely without compromising rCBF? On the basis of experience with 155 patients, the management and understanding of cerebrovascular disease has been aided substantially by the incorporation of rCBF mapping by xenon-enhanced CT scan in the evaluation of these patients.
AB - CT scanning performed before and sequentially during the inhalation of stable xenon (32%), coupled with end-tidal xenon measurements, has made possible the routine construction of regional cerebral blood flow (rCBF) maps with resolution that approximates that of the CT scanner. The capability of obtaining quantitative flow maps with direct anatomic correlation is now available with a commercial package of hardware and software adapted to the General Electric 9800 scanner. The ability to distinguish between normal and reduced rCBF in specific vascular territories has proved useful in the management of cerebrovascular disease. Specific clinical dilemmas that have been addressed with rCBF information from xenon-enhanced CT scanning include the following: (1) In the patient with asymptomatic occlusive disease, is normal rCBF preserved? Is there adequate collateral flow? (2) Are cerebrovascular symptoms a result of emboli or chronic regional low flow? (3) In the patient with complex multivessel occlusive disease, which revascularization procedure is indicated first? Did operation improve rCBF? Should a further procedure be added? (4) May a diffusely diseased but patent artery, which is the source of emboli, be sacrificed safely without compromising rCBF? On the basis of experience with 155 patients, the management and understanding of cerebrovascular disease has been aided substantially by the incorporation of rCBF mapping by xenon-enhanced CT scan in the evaluation of these patients.
UR - http://www.scopus.com/inward/record.url?scp=0022616637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022616637&partnerID=8YFLogxK
U2 - 10.1016/0741-5214(86)90014-5
DO - 10.1016/0741-5214(86)90014-5
M3 - Article
C2 - 3484790
AN - SCOPUS:0022616637
VL - 3
SP - 298
EP - 304
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
SN - 0741-5214
IS - 2
ER -