Cerebral blood flow and metabolism in severely head-injured children Part 1

Relationship with GCS score, outcome, ICP, and PVI

Jan Paul Muizelaar, A. Marmarou, A. A F DeSalles, J. D. Ward, R. S. Zimmerman, Z. Li, S. C. Choi, H. F. Young

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

The literature suggests that in children with severe head injury, cerebral hyperemia is common and related to high intracranial pressure (ICP). However, there are very few data on cerebral blood flow (CBF) after severe head injury in children. This paper presents 72 measurements of cerebral blood flow ('CBF15'), using the 133Xe inhalation method, with multiple detectors over both hemispheres in 32 children aged 3 to 18 years (mean 13.6 years) with severe closed head injury (average Glasgow Coma Scale (GCS) score 5.4). In 25 of the children, these were combined with measurements of arteriojugular venous oxygen difference (AVDO2) and of cerebral metabolic rate of oxygen (CMRO2). In 30 patients, the first measurement was taken approximately 12 hours postinjury. In 18 patients, an indication of brain stiffness was obtained by withdrawal and injection of ventricular cerebrospinal fluid and calculation of the pressure-volume index (PVI) of Marmarou. The CBF and CMRO2 data were correlated with the GCS score, outcome, ICP, and PVI. Early after injury, CBF tended to be lower GCS scores, but this was not statistically significant. This trend was reversed 24 hours postinjury, as significantly more hyperemic values were recorded the lower the GCS score, with the exception of the most severely injured patients (GCS score 3). In contrast, mean CMRO2 correlated positively with the GCS score and outcome throughout the course, but large standard deviations preclude making predictions based on CMRO2 measurements in individual patients. Early after injury, there was mild uncoupling between CBF and CMRO2 (CBF above metabolic demands, low AVDO2) and, after 24 hours, flow and metabolism were completely uncoupled with an extremely low AVDO2. Consistently reduced flow was found in only four patients; 28 patients (88%) showed hyperemia at some point in their course. This very high percentage of patients with hyperemia, combined with the lowest values of AVDO2 found in the literature, indicates that hyperemia or luxury perfusion is more prevalent in this group of patients. The three patients with consistently the highest CBF had consistently the lowest PVI: thus, the patients with the most severe hyperemia also had the stiffest brains. Nevertheless, and in contrast to previous reports, no correlation could be established between the course of ICP or PVI and the occurrence of hyperemia, nor was there a correlation between the levels of CBF and ICP at the time of the measurements. The authors argue that this lack of correlation is due to: 1) a definition of hyperemia that is too generous, and 2) the lack of a systematic relationship between CBF and cerebral blood volume. The implications of these findings for therapeutic modes of controlling ICP in children, such as hyperventilation and the use of mannitol, are discussed.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalJournal of Neurosurgery
Volume71
Issue number1
StatePublished - 1989
Externally publishedYes

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Cerebrovascular Circulation
Glasgow Coma Scale
Intracranial Pressure
Hyperemia
Head
Pressure
Craniocerebral Trauma
Oxygen
Cerebrospinal Fluid Pressure
Closed Head Injuries
Hyperventilation
Wounds and Injuries
Brain
Mannitol
Inhalation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Muizelaar, J. P., Marmarou, A., DeSalles, A. A. F., Ward, J. D., Zimmerman, R. S., Li, Z., ... Young, H. F. (1989). Cerebral blood flow and metabolism in severely head-injured children Part 1: Relationship with GCS score, outcome, ICP, and PVI. Journal of Neurosurgery, 71(1), 63-71.

Cerebral blood flow and metabolism in severely head-injured children Part 1 : Relationship with GCS score, outcome, ICP, and PVI. / Muizelaar, Jan Paul; Marmarou, A.; DeSalles, A. A F; Ward, J. D.; Zimmerman, R. S.; Li, Z.; Choi, S. C.; Young, H. F.

In: Journal of Neurosurgery, Vol. 71, No. 1, 1989, p. 63-71.

Research output: Contribution to journalArticle

Muizelaar, JP, Marmarou, A, DeSalles, AAF, Ward, JD, Zimmerman, RS, Li, Z, Choi, SC & Young, HF 1989, 'Cerebral blood flow and metabolism in severely head-injured children Part 1: Relationship with GCS score, outcome, ICP, and PVI', Journal of Neurosurgery, vol. 71, no. 1, pp. 63-71.
Muizelaar, Jan Paul ; Marmarou, A. ; DeSalles, A. A F ; Ward, J. D. ; Zimmerman, R. S. ; Li, Z. ; Choi, S. C. ; Young, H. F. / Cerebral blood flow and metabolism in severely head-injured children Part 1 : Relationship with GCS score, outcome, ICP, and PVI. In: Journal of Neurosurgery. 1989 ; Vol. 71, No. 1. pp. 63-71.
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N2 - The literature suggests that in children with severe head injury, cerebral hyperemia is common and related to high intracranial pressure (ICP). However, there are very few data on cerebral blood flow (CBF) after severe head injury in children. This paper presents 72 measurements of cerebral blood flow ('CBF15'), using the 133Xe inhalation method, with multiple detectors over both hemispheres in 32 children aged 3 to 18 years (mean 13.6 years) with severe closed head injury (average Glasgow Coma Scale (GCS) score 5.4). In 25 of the children, these were combined with measurements of arteriojugular venous oxygen difference (AVDO2) and of cerebral metabolic rate of oxygen (CMRO2). In 30 patients, the first measurement was taken approximately 12 hours postinjury. In 18 patients, an indication of brain stiffness was obtained by withdrawal and injection of ventricular cerebrospinal fluid and calculation of the pressure-volume index (PVI) of Marmarou. The CBF and CMRO2 data were correlated with the GCS score, outcome, ICP, and PVI. Early after injury, CBF tended to be lower GCS scores, but this was not statistically significant. This trend was reversed 24 hours postinjury, as significantly more hyperemic values were recorded the lower the GCS score, with the exception of the most severely injured patients (GCS score 3). In contrast, mean CMRO2 correlated positively with the GCS score and outcome throughout the course, but large standard deviations preclude making predictions based on CMRO2 measurements in individual patients. Early after injury, there was mild uncoupling between CBF and CMRO2 (CBF above metabolic demands, low AVDO2) and, after 24 hours, flow and metabolism were completely uncoupled with an extremely low AVDO2. Consistently reduced flow was found in only four patients; 28 patients (88%) showed hyperemia at some point in their course. This very high percentage of patients with hyperemia, combined with the lowest values of AVDO2 found in the literature, indicates that hyperemia or luxury perfusion is more prevalent in this group of patients. The three patients with consistently the highest CBF had consistently the lowest PVI: thus, the patients with the most severe hyperemia also had the stiffest brains. Nevertheless, and in contrast to previous reports, no correlation could be established between the course of ICP or PVI and the occurrence of hyperemia, nor was there a correlation between the levels of CBF and ICP at the time of the measurements. The authors argue that this lack of correlation is due to: 1) a definition of hyperemia that is too generous, and 2) the lack of a systematic relationship between CBF and cerebral blood volume. The implications of these findings for therapeutic modes of controlling ICP in children, such as hyperventilation and the use of mannitol, are discussed.

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