Abstract
We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1592-1596 |
| Number of pages | 5 |
| Journal | Neurology |
| Volume | 46 |
| Issue number | 6 |
| State | Published - Jun 1996 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease : The CERAD experience, part XV. / Ellis, R. J.; Olichney, John M; Thal, L. J.; Mirra, S. S.; Morris, J. C.; Beekly, D.; Heyman, A.
In: Neurology, Vol. 46, No. 6, 06.1996, p. 1592-1596.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease
T2 - The CERAD experience, part XV
AU - Ellis, R. J.
AU - Olichney, John M
AU - Thal, L. J.
AU - Mirra, S. S.
AU - Morris, J. C.
AU - Beekly, D.
AU - Heyman, A.
PY - 1996/6
Y1 - 1996/6
N2 - We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.
AB - We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.
UR - http://www.scopus.com/inward/record.url?scp=0029973286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029973286&partnerID=8YFLogxK
M3 - Article
C2 - 8649554
AN - SCOPUS:0029973286
VL - 46
SP - 1592
EP - 1596
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 6
ER -