Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

R. J. Ellis, John M Olichney, L. J. Thal, S. S. Mirra, J. C. Morris, D. Beekly, A. Heyman

Research output: Contribution to journalArticle

394 Scopus citations

Abstract

We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.

Original languageEnglish (US)
Pages (from-to)1592-1596
Number of pages5
JournalNeurology
Volume46
Issue number6
StatePublished - Jun 1996

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996). Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV. Neurology, 46(6), 1592-1596.