Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease

The CERAD experience, part XV

R. J. Ellis, John M Olichney, L. J. Thal, S. S. Mirra, J. C. Morris, D. Beekly, A. Heyman

Research output: Contribution to journalArticle

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Abstract

We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.

Original languageEnglish (US)
Pages (from-to)1592-1596
Number of pages5
JournalNeurology
Volume46
Issue number6
StatePublished - Jun 1996

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Cerebral Amyloid Angiopathy
Alzheimer Disease
Brain
Intracranial Arteriosclerosis
Age of Onset
Amyloid
Blood Vessels
Dementia
Autopsy
Atherosclerosis
Odds Ratio
Pathology
Hemorrhage
Amyloid angiopathy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996). Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV. Neurology, 46(6), 1592-1596.

Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease : The CERAD experience, part XV. / Ellis, R. J.; Olichney, John M; Thal, L. J.; Mirra, S. S.; Morris, J. C.; Beekly, D.; Heyman, A.

In: Neurology, Vol. 46, No. 6, 06.1996, p. 1592-1596.

Research output: Contribution to journalArticle

Ellis, RJ, Olichney, JM, Thal, LJ, Mirra, SS, Morris, JC, Beekly, D & Heyman, A 1996, 'Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV', Neurology, vol. 46, no. 6, pp. 1592-1596.
Ellis, R. J. ; Olichney, John M ; Thal, L. J. ; Mirra, S. S. ; Morris, J. C. ; Beekly, D. ; Heyman, A. / Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease : The CERAD experience, part XV. In: Neurology. 1996 ; Vol. 46, No. 6. pp. 1592-1596.
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