Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

R. J. Ellis; John M Olichney; L. J. Thal; S. S. Mirra; J. C. Morris; D. Beekly; A. Heyman

Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

R. J. Ellis, John M Olichney, L. J. Thal, S. S. Mirra, J. C. Morris, D. Beekly, A. Heyman

Neurology

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431 Scopus citations

Abstract

We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.

Original language	English (US)
Pages (from-to)	1592-1596
Number of pages	5
Journal	Neurology
Volume	46
Issue number	6
State	Published - Jun 1996

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.",

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AU - Olichney, John M

AU - Thal, L. J.

AU - Mirra, S. S.

AU - Morris, J. C.

AU - Beekly, D.

AU - Heyman, A.

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AB - We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.

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Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

Abstract

ASJC Scopus subject areas

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