Abstract
Apoptotic cell death was originally distinguished from necrosis based on morphological differences and on the tendency of necrotic, but not apoptotic, cells to induce an inflammatory response. Although it is still not clear how necrotic cells trigger inflammation, this capacity may be critical in relating tissue damage to the generation of an immune response. Ceramide has received substantial interest for its modulatory role in the path of programmed cell death (apoptosis). These studies have led to new understanding of some of the underlying pathology of several diseases with imbalances in the ceramide metabolism leading to undesired cell activation, imbalance in apoptosis and inflammatory processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-179 |
| Number of pages | 7 |
| Journal | Clinical and Applied Immunology Reviews |
| Volume | 1 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Apoptosis
- Autoimmune diseases
- Ceramide
ASJC Scopus subject areas
- Immunology
- Microbiology
- Immunology and Allergy
- Infectious Diseases
Cite this
Ceramide generation and apoptosis in autoimmunity. / Goldkorn, Tzipora.
In: Clinical and Applied Immunology Reviews, Vol. 1, No. 3-4, 2001, p. 173-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ceramide generation and apoptosis in autoimmunity
AU - Goldkorn, Tzipora
PY - 2001
Y1 - 2001
N2 - Apoptotic cell death was originally distinguished from necrosis based on morphological differences and on the tendency of necrotic, but not apoptotic, cells to induce an inflammatory response. Although it is still not clear how necrotic cells trigger inflammation, this capacity may be critical in relating tissue damage to the generation of an immune response. Ceramide has received substantial interest for its modulatory role in the path of programmed cell death (apoptosis). These studies have led to new understanding of some of the underlying pathology of several diseases with imbalances in the ceramide metabolism leading to undesired cell activation, imbalance in apoptosis and inflammatory processes.
AB - Apoptotic cell death was originally distinguished from necrosis based on morphological differences and on the tendency of necrotic, but not apoptotic, cells to induce an inflammatory response. Although it is still not clear how necrotic cells trigger inflammation, this capacity may be critical in relating tissue damage to the generation of an immune response. Ceramide has received substantial interest for its modulatory role in the path of programmed cell death (apoptosis). These studies have led to new understanding of some of the underlying pathology of several diseases with imbalances in the ceramide metabolism leading to undesired cell activation, imbalance in apoptosis and inflammatory processes.
KW - Apoptosis
KW - Autoimmune diseases
KW - Ceramide
UR - http://www.scopus.com/inward/record.url?scp=3142587410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3142587410&partnerID=8YFLogxK
U2 - 10.1016/S1529-1049(01)00011-3
DO - 10.1016/S1529-1049(01)00011-3
M3 - Article
VL - 1
SP - 173
EP - 179
JO - Clinical and Applied Immunology Reviews
JF - Clinical and Applied Immunology Reviews
SN - 1529-1049
IS - 3-4
ER -