TY - JOUR
T1 - Centrosomes and tumour suppressors
AU - Fisk, Harold A.
AU - Mattison, Christopher P.
AU - Winey, Mark
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Centrosomes are microtubule organising centres that act as spindle poles during mitosis. Recent work implicates centrosomes in many other processes, and shows that centrosome defects can cause genetic instability. Many regulators of mammalian centrosome function were predicted from studies of model systems. Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability.
AB - Centrosomes are microtubule organising centres that act as spindle poles during mitosis. Recent work implicates centrosomes in many other processes, and shows that centrosome defects can cause genetic instability. Many regulators of mammalian centrosome function were predicted from studies of model systems. Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability.
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U2 - 10.1016/S0955-0674(02)00385-X
DO - 10.1016/S0955-0674(02)00385-X
M3 - Review article
C2 - 12473342
AN - SCOPUS:0036899047
VL - 14
SP - 700
EP - 705
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 6
ER -