Centrosomes and tumour suppressors

Harold A. Fisk, Christopher P. Mattison, Mark Winey

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Centrosomes are microtubule organising centres that act as spindle poles during mitosis. Recent work implicates centrosomes in many other processes, and shows that centrosome defects can cause genetic instability. Many regulators of mammalian centrosome function were predicted from studies of model systems. Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability.

Original languageEnglish (US)
Pages (from-to)700-705
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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