Central obesity and the aging brain

William Jagust, Danielle J Harvey, Dan M Mungas, Mary Haan

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Background: Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia. Objective: To determine whether larger waist-hip ratio (WHR) is associated with structural brain changes that underlie cognitive decline and dementia. Design: Cross-sectional analysis of an epidemiologic cohort study of cognitive and functional decline (Sacramento Area Latino Study on Aging). Setting: California Central Valley. Participants: A total of 112 individuals selected from an ongoing cohort study of 1789 older Latino individuals. Baseline anthropomorphic measures (WHR) and measurements of fasting blood glucose, cholesterol, and insulin levels and blood pressure were obtained. Main Outcome Measures: Baseline magnetic resonance images were analyzed quantitatively to determine the hippocampal volumes in the right and left hemispheres and rated for the percentage of white matter hyperintensities. Results: Greater WHR (P=.02) and older age (P<.001) were negatively related to hippocampal volumes. The WHR and age were positively related to white matter hyperintensities (P=.02 and P=.001, respectively). A 1-SD increase in WHR was associated with a 0.2-SD decrease in hippocampal volume and a 27% increase in white matter hyperintensities. These relationships were not affected by adjustment for body mass index, total cholesterol, fasting blood glucose, and insulin levels or systolic blood pressure in the models. Conclusion: A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.

Original languageEnglish (US)
Pages (from-to)1545-1548
Number of pages4
JournalArchives of Neurology
Volume62
Issue number10
DOIs
StatePublished - Oct 2005

Fingerprint

Waist-Hip Ratio
Abdominal Obesity
Brain
Dementia
Blood Pressure
Hispanic Americans
Blood Glucose
Fasting
Cohort Studies
Cholesterol
Insulin
Intra-Abdominal Fat
Adiposity
Blood Vessels
Obesity
Epidemiologic Studies
Body Mass Index
Magnetic Resonance Spectroscopy
Cross-Sectional Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Central obesity and the aging brain. / Jagust, William; Harvey, Danielle J; Mungas, Dan M; Haan, Mary.

In: Archives of Neurology, Vol. 62, No. 10, 10.2005, p. 1545-1548.

Research output: Contribution to journalArticle

Jagust, William ; Harvey, Danielle J ; Mungas, Dan M ; Haan, Mary. / Central obesity and the aging brain. In: Archives of Neurology. 2005 ; Vol. 62, No. 10. pp. 1545-1548.
@article{eee55d361a294eb996f482561ff06939,
title = "Central obesity and the aging brain",
abstract = "Background: Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia. Objective: To determine whether larger waist-hip ratio (WHR) is associated with structural brain changes that underlie cognitive decline and dementia. Design: Cross-sectional analysis of an epidemiologic cohort study of cognitive and functional decline (Sacramento Area Latino Study on Aging). Setting: California Central Valley. Participants: A total of 112 individuals selected from an ongoing cohort study of 1789 older Latino individuals. Baseline anthropomorphic measures (WHR) and measurements of fasting blood glucose, cholesterol, and insulin levels and blood pressure were obtained. Main Outcome Measures: Baseline magnetic resonance images were analyzed quantitatively to determine the hippocampal volumes in the right and left hemispheres and rated for the percentage of white matter hyperintensities. Results: Greater WHR (P=.02) and older age (P<.001) were negatively related to hippocampal volumes. The WHR and age were positively related to white matter hyperintensities (P=.02 and P=.001, respectively). A 1-SD increase in WHR was associated with a 0.2-SD decrease in hippocampal volume and a 27{\%} increase in white matter hyperintensities. These relationships were not affected by adjustment for body mass index, total cholesterol, fasting blood glucose, and insulin levels or systolic blood pressure in the models. Conclusion: A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.",
author = "William Jagust and Harvey, {Danielle J} and Mungas, {Dan M} and Mary Haan",
year = "2005",
month = "10",
doi = "10.1001/archneur.62.10.1545",
language = "English (US)",
volume = "62",
pages = "1545--1548",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "10",

}

TY - JOUR

T1 - Central obesity and the aging brain

AU - Jagust, William

AU - Harvey, Danielle J

AU - Mungas, Dan M

AU - Haan, Mary

PY - 2005/10

Y1 - 2005/10

N2 - Background: Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia. Objective: To determine whether larger waist-hip ratio (WHR) is associated with structural brain changes that underlie cognitive decline and dementia. Design: Cross-sectional analysis of an epidemiologic cohort study of cognitive and functional decline (Sacramento Area Latino Study on Aging). Setting: California Central Valley. Participants: A total of 112 individuals selected from an ongoing cohort study of 1789 older Latino individuals. Baseline anthropomorphic measures (WHR) and measurements of fasting blood glucose, cholesterol, and insulin levels and blood pressure were obtained. Main Outcome Measures: Baseline magnetic resonance images were analyzed quantitatively to determine the hippocampal volumes in the right and left hemispheres and rated for the percentage of white matter hyperintensities. Results: Greater WHR (P=.02) and older age (P<.001) were negatively related to hippocampal volumes. The WHR and age were positively related to white matter hyperintensities (P=.02 and P=.001, respectively). A 1-SD increase in WHR was associated with a 0.2-SD decrease in hippocampal volume and a 27% increase in white matter hyperintensities. These relationships were not affected by adjustment for body mass index, total cholesterol, fasting blood glucose, and insulin levels or systolic blood pressure in the models. Conclusion: A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.

AB - Background: Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia. Objective: To determine whether larger waist-hip ratio (WHR) is associated with structural brain changes that underlie cognitive decline and dementia. Design: Cross-sectional analysis of an epidemiologic cohort study of cognitive and functional decline (Sacramento Area Latino Study on Aging). Setting: California Central Valley. Participants: A total of 112 individuals selected from an ongoing cohort study of 1789 older Latino individuals. Baseline anthropomorphic measures (WHR) and measurements of fasting blood glucose, cholesterol, and insulin levels and blood pressure were obtained. Main Outcome Measures: Baseline magnetic resonance images were analyzed quantitatively to determine the hippocampal volumes in the right and left hemispheres and rated for the percentage of white matter hyperintensities. Results: Greater WHR (P=.02) and older age (P<.001) were negatively related to hippocampal volumes. The WHR and age were positively related to white matter hyperintensities (P=.02 and P=.001, respectively). A 1-SD increase in WHR was associated with a 0.2-SD decrease in hippocampal volume and a 27% increase in white matter hyperintensities. These relationships were not affected by adjustment for body mass index, total cholesterol, fasting blood glucose, and insulin levels or systolic blood pressure in the models. Conclusion: A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.

UR - http://www.scopus.com/inward/record.url?scp=26444458863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26444458863&partnerID=8YFLogxK

U2 - 10.1001/archneur.62.10.1545

DO - 10.1001/archneur.62.10.1545

M3 - Article

VL - 62

SP - 1545

EP - 1548

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 10

ER -