Central nervous system transcriptome of Biomphalaria alexandrina, an intermediate host for schistosomiasis

Tamer A. Mansour, Mohamed R. Habib, Laura C.Vicente Rodríguez, Anthony Hernández Vázquez, Julián Maldonado Alers, Alfredo Ghezzi, Roger P. Croll, Charles Brown, Mark W. Miller

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objective: Globally, more than 200 million people live at risk of the neglected tropical disease schistosomiasis (or snail fever). Larval schistosomes require the presence of specific snail species that act as intermediate hosts, supporting their multiplication and transformation into forms that can infect humans. This project was designed to generate a transcriptome from the central nervous system (CNS) of Biomphalaria alexandrina, the major intermediate host for Schistosoma mansoni in Egypt. Results: A transcriptome was generated from five pooled central nervous systems dissected from uninfected specimens of B. alexandrina. Raw Illumina RNA-seq data (∼ 20.3 million paired end reads of 150 base pairs length each) generated a transcriptome consisting of 144,213 transcript elements with an N50 contig size of 716 base pairs. Orthologs of 15,246 transcripts and homologs for an additional 16,810 transcripts were identified in the UniProtKB/Swiss-Prot database. The B. alexandrina CNS transcriptome provides a resource for future research exploring parasite-host interactions in a simpler nervous system. Moreover, increased understanding of the neural signaling mechanisms involved in the response of B. alexandrina to infection by S. mansoni larvae could lead to novel and highly specific strategies for the control of snail populations.

Original languageEnglish (US)
Article number729
JournalBMC Research Notes
Issue number1
StatePublished - Dec 11 2017


  • Biomphalaria alexandrina
  • CNS
  • Gastropod
  • Mollusk
  • Nile
  • Schistosoma mansoni
  • Trematode

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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