Central nervous system opiate and 5-hydroxytryptamine influences on baroreflex control of the coronary circulation

Peter G Moore, W. L. Porges, G. J. Gazibarich, S. W. White

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of intravenous infusion of fentanyl (an opiate receptor agonist, 0.55 μg kg-1 min-1) on the control of the circumflex coronary circulation was examined in unsedated dogs at rest and during baroreceptor stimulation evoked by acute rises in aortic pressure (balloon inflation in thoracic aorta). Circumflex flow was measured using Doppler flow transducers in dogs with experimental complete heart block and with ventricles paced at a constant rate. Studies were also performed before and one week after intracisternal injection of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), to examine the role of CNS 5-hydroxytryptamine (5-HT) in any sympathetic vasoconstrictive effects. Fentanyl infusion caused after a few minutes a progressive rise in resting aortic pressure and a significant fall in circumflex conductance; circumflex flow usually fell. Atrial rate also fell. The gain of the baroreflex control of circumflex conductance was enhanced by fentanyl. One week after intracisternal 5,7-DHT, the gain of the baroreflex in each dog was diminished. When fentanyl was infused into these preparations, no consistent changes in resting atrial rate, aortic pressure and circumflex conductance could be observed, but all dogs showed a recovery of the coronary baroreflex gain towards values observed before intracisternal 5,7-DHT. These data suggest that the gain control of coronary baroreflexes is influenced by CNS opiate and 5-HT dependent mechanisms.

Original languageEnglish (US)
Pages (from-to)185-194
Number of pages10
JournalJournal of the Autonomic Nervous System
Volume12
Issue number2-3
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Opiate Alkaloids
Coronary Circulation
Baroreflex
Fentanyl
Serotonin
Central Nervous System
5,7-Dihydroxytryptamine
Dogs
Arterial Pressure
Dihydroxytryptamines
Pressoreceptors
Heart Block
Economic Inflation
Opioid Receptors
Transducers
Thoracic Aorta
Intravenous Infusions
Injections

Keywords

  • 5-hydroxytryptamine
  • baroreflex
  • central nervous system
  • coronary conductance
  • fentanyl
  • opiate

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Central nervous system opiate and 5-hydroxytryptamine influences on baroreflex control of the coronary circulation. / Moore, Peter G; Porges, W. L.; Gazibarich, G. J.; White, S. W.

In: Journal of the Autonomic Nervous System, Vol. 12, No. 2-3, 1985, p. 185-194.

Research output: Contribution to journalArticle

Moore, Peter G ; Porges, W. L. ; Gazibarich, G. J. ; White, S. W. / Central nervous system opiate and 5-hydroxytryptamine influences on baroreflex control of the coronary circulation. In: Journal of the Autonomic Nervous System. 1985 ; Vol. 12, No. 2-3. pp. 185-194.
@article{1d78d2aba7084861a4f9e8f37451ec92,
title = "Central nervous system opiate and 5-hydroxytryptamine influences on baroreflex control of the coronary circulation",
abstract = "The effect of intravenous infusion of fentanyl (an opiate receptor agonist, 0.55 μg kg-1 min-1) on the control of the circumflex coronary circulation was examined in unsedated dogs at rest and during baroreceptor stimulation evoked by acute rises in aortic pressure (balloon inflation in thoracic aorta). Circumflex flow was measured using Doppler flow transducers in dogs with experimental complete heart block and with ventricles paced at a constant rate. Studies were also performed before and one week after intracisternal injection of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), to examine the role of CNS 5-hydroxytryptamine (5-HT) in any sympathetic vasoconstrictive effects. Fentanyl infusion caused after a few minutes a progressive rise in resting aortic pressure and a significant fall in circumflex conductance; circumflex flow usually fell. Atrial rate also fell. The gain of the baroreflex control of circumflex conductance was enhanced by fentanyl. One week after intracisternal 5,7-DHT, the gain of the baroreflex in each dog was diminished. When fentanyl was infused into these preparations, no consistent changes in resting atrial rate, aortic pressure and circumflex conductance could be observed, but all dogs showed a recovery of the coronary baroreflex gain towards values observed before intracisternal 5,7-DHT. These data suggest that the gain control of coronary baroreflexes is influenced by CNS opiate and 5-HT dependent mechanisms.",
keywords = "5-hydroxytryptamine, baroreflex, central nervous system, coronary conductance, fentanyl, opiate",
author = "Moore, {Peter G} and Porges, {W. L.} and Gazibarich, {G. J.} and White, {S. W.}",
year = "1985",
doi = "10.1016/0165-1838(85)90060-8",
language = "English (US)",
volume = "12",
pages = "185--194",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Central nervous system opiate and 5-hydroxytryptamine influences on baroreflex control of the coronary circulation

AU - Moore, Peter G

AU - Porges, W. L.

AU - Gazibarich, G. J.

AU - White, S. W.

PY - 1985

Y1 - 1985

N2 - The effect of intravenous infusion of fentanyl (an opiate receptor agonist, 0.55 μg kg-1 min-1) on the control of the circumflex coronary circulation was examined in unsedated dogs at rest and during baroreceptor stimulation evoked by acute rises in aortic pressure (balloon inflation in thoracic aorta). Circumflex flow was measured using Doppler flow transducers in dogs with experimental complete heart block and with ventricles paced at a constant rate. Studies were also performed before and one week after intracisternal injection of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), to examine the role of CNS 5-hydroxytryptamine (5-HT) in any sympathetic vasoconstrictive effects. Fentanyl infusion caused after a few minutes a progressive rise in resting aortic pressure and a significant fall in circumflex conductance; circumflex flow usually fell. Atrial rate also fell. The gain of the baroreflex control of circumflex conductance was enhanced by fentanyl. One week after intracisternal 5,7-DHT, the gain of the baroreflex in each dog was diminished. When fentanyl was infused into these preparations, no consistent changes in resting atrial rate, aortic pressure and circumflex conductance could be observed, but all dogs showed a recovery of the coronary baroreflex gain towards values observed before intracisternal 5,7-DHT. These data suggest that the gain control of coronary baroreflexes is influenced by CNS opiate and 5-HT dependent mechanisms.

AB - The effect of intravenous infusion of fentanyl (an opiate receptor agonist, 0.55 μg kg-1 min-1) on the control of the circumflex coronary circulation was examined in unsedated dogs at rest and during baroreceptor stimulation evoked by acute rises in aortic pressure (balloon inflation in thoracic aorta). Circumflex flow was measured using Doppler flow transducers in dogs with experimental complete heart block and with ventricles paced at a constant rate. Studies were also performed before and one week after intracisternal injection of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), to examine the role of CNS 5-hydroxytryptamine (5-HT) in any sympathetic vasoconstrictive effects. Fentanyl infusion caused after a few minutes a progressive rise in resting aortic pressure and a significant fall in circumflex conductance; circumflex flow usually fell. Atrial rate also fell. The gain of the baroreflex control of circumflex conductance was enhanced by fentanyl. One week after intracisternal 5,7-DHT, the gain of the baroreflex in each dog was diminished. When fentanyl was infused into these preparations, no consistent changes in resting atrial rate, aortic pressure and circumflex conductance could be observed, but all dogs showed a recovery of the coronary baroreflex gain towards values observed before intracisternal 5,7-DHT. These data suggest that the gain control of coronary baroreflexes is influenced by CNS opiate and 5-HT dependent mechanisms.

KW - 5-hydroxytryptamine

KW - baroreflex

KW - central nervous system

KW - coronary conductance

KW - fentanyl

KW - opiate

UR - http://www.scopus.com/inward/record.url?scp=0021964535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021964535&partnerID=8YFLogxK

U2 - 10.1016/0165-1838(85)90060-8

DO - 10.1016/0165-1838(85)90060-8

M3 - Article

C2 - 2987334

AN - SCOPUS:0021964535

VL - 12

SP - 185

EP - 194

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 2-3

ER -