Central nervous system action of calcitonin gene-related peptide to inhibit gastric emptying in the conscious rat

Helen E Raybould, Elizabeth Kolve, Yvette Taché

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The central nervous system action of rat α-calcitonin gene-related peptide (α-CGRP) on gastric emptying of a liquid, noncaloric, methylcellulose solution was assessed in 24-hr fasted, conscious rats using phenol red method as a marker. Intracisternal injection of α-CGRP (0.75-250 pmol) dose-dependently inhibited gastric emptying by 27-94% as measured 20 min after oral administration of the solution. The ED50 was 6.2 pmol. α-CGRP injected intravenously at 250 pmol delayed gastric emptying by 71% whereas a lower dose (75 pmol) was inactive. Intracisternal α-CGRP-induced inhibition of gastric emptying was completely abolished by bilateral adrenalectomy and partially suppressed by subdiaphragmatic vagotomy or coeliac/superior mesenteric ganglionectomy. Adrenalectomy or vagotomy in saline-treated animals did not significantly modify the rate of gastric emptying whereas coeliac/superior mesenteric ganglionectomy caused a significant 29% inhibition as compared to the nonoperated group. These results demonstrate that α-CGRP is a potent centrally acting inhibitor of gastric emptying of a nonnutrient liquid. The inhibitory effect of intracisternal injection of CGRP appears to be mediated by the adrenal gland and in part by the sympathetic and parasympathetic nervous system.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalPeptides
Volume9
Issue number4
DOIs
StatePublished - 1988

Keywords

  • Adrenal glands
  • CGRP
  • CNS
  • Coeliac ganglion
  • Gastric emptying
  • Vagus

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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