Abstract
Cough is the most common symptom for which individuals seek medical attention and spend health-care dollars. Despite the burden induced by cough, the current treatments for cough are only partially effective. Delineating the sites and mechanisms in the cough central network for changes in the cough reflex could lead to new therapeutic strategies and drug target sites for more effective treatments. The first synaptic target in the CNS for the cough-related sensory input is the secondorder neurons in the nucleus tractus solitarius (NTS); these neurons reorganize the primary sensory information into a coherent output. The NTS neurons have been shown to undergo neuroplasticity under a variety of conditions, such as respiratory disorders, stress, and exposures to environmental pollutants. The NTS contains a rich innervation of substance P immunoreactive nerve terminals, suggesting that substance P might be important in altered cough reflex response. This chapter summarizes our current findings on the role of substance P in enhanced cough reflex as well as the potential NTS targets for the action of substance P.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-201 |
| Number of pages | 15 |
| Journal | Handbook of Experimental Pharmacology |
| Volume | 187 |
| DOIs | |
| State | Published - 2009 |
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ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Biochemistry
- Medicine(all)
Cite this
Central mechanisms I : Plasticity of central pathways. / Bonham, A. C.; Chen, C. Y.; Joad, J. P.; Bric, J.
In: Handbook of Experimental Pharmacology, Vol. 187, 2009, p. 187-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Central mechanisms I
T2 - Plasticity of central pathways
AU - Bonham, A. C.
AU - Chen, C. Y.
AU - Joad, J. P.
AU - Bric, J.
PY - 2009
Y1 - 2009
N2 - Cough is the most common symptom for which individuals seek medical attention and spend health-care dollars. Despite the burden induced by cough, the current treatments for cough are only partially effective. Delineating the sites and mechanisms in the cough central network for changes in the cough reflex could lead to new therapeutic strategies and drug target sites for more effective treatments. The first synaptic target in the CNS for the cough-related sensory input is the secondorder neurons in the nucleus tractus solitarius (NTS); these neurons reorganize the primary sensory information into a coherent output. The NTS neurons have been shown to undergo neuroplasticity under a variety of conditions, such as respiratory disorders, stress, and exposures to environmental pollutants. The NTS contains a rich innervation of substance P immunoreactive nerve terminals, suggesting that substance P might be important in altered cough reflex response. This chapter summarizes our current findings on the role of substance P in enhanced cough reflex as well as the potential NTS targets for the action of substance P.
AB - Cough is the most common symptom for which individuals seek medical attention and spend health-care dollars. Despite the burden induced by cough, the current treatments for cough are only partially effective. Delineating the sites and mechanisms in the cough central network for changes in the cough reflex could lead to new therapeutic strategies and drug target sites for more effective treatments. The first synaptic target in the CNS for the cough-related sensory input is the secondorder neurons in the nucleus tractus solitarius (NTS); these neurons reorganize the primary sensory information into a coherent output. The NTS neurons have been shown to undergo neuroplasticity under a variety of conditions, such as respiratory disorders, stress, and exposures to environmental pollutants. The NTS contains a rich innervation of substance P immunoreactive nerve terminals, suggesting that substance P might be important in altered cough reflex response. This chapter summarizes our current findings on the role of substance P in enhanced cough reflex as well as the potential NTS targets for the action of substance P.
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UR - http://www.scopus.com/inward/citedby.url?scp=56049122446&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-79842-2_9
DO - 10.1007/978-3-540-79842-2_9
M3 - Article
C2 - 18825341
AN - SCOPUS:56049122446
VL - 187
SP - 187
EP - 201
JO - Handbook of Experimental Pharmacology
JF - Handbook of Experimental Pharmacology
SN - 0171-2004
ER -