Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB)

Mu Yang, Catherine Farrokhi, Amy Vasconcellos, Robert J. Blanchard, D. Caroline Blanchard

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Following intracerebroventricular (i.c.v.) injection of ovine CRF (oCRF), an endogenous peptide agonist at both CRF1 and CRF2 receptors, defensive behaviors of CD-1 mice were evaluated in the Mouse Defensive Test Battery (MDTB). Behavioral measures taken before, during, and after predator (a hand-held anesthetized rat) confrontation included exploratory activity, risk assessment, avoidance, flight, freezing, defensive threat/attack, and residual emotional responses. Both low (0.1 nmol) and high (0.2 nmol) doses of oCRF robustly suppressed exploratory activities and increased risk assessment during the initial familiarization period. Flight speed and jump escapes when the mouse was chased were significantly elevated by the 0.2 nmol dose. Both doses enhanced freezing and avoidance to a distant predator when the escape route was blocked. The 0.2 nmol dose also potentiated flight responses to a contacting predator in a highly confined space. Both oCRF groups traveled shorter distances and exhibited less escape attempts following the removal of the threat stimulus. These findings indicate that non-selective activation of corticotropin-releasing factor (CRF) receptors via ventricular infusion of oCRF potentiates defensive behaviors relevant to the demand of specific challenges, generally enhancing the predominant defensive behavior in each specific situation.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBehavioural Brain Research
Volume171
Issue number1
DOIs
StatePublished - Jul 15 2006
Externally publishedYes

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Corticotropin-Releasing Hormone
Sheep
Freezing
Confined Spaces
Corticotropin-Releasing Hormone Receptors
Hand
Peptides
Injections

Keywords

  • CRF agonist
  • Defensive behaviors
  • Mice
  • oCRF

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB). / Yang, Mu; Farrokhi, Catherine; Vasconcellos, Amy; Blanchard, Robert J.; Blanchard, D. Caroline.

In: Behavioural Brain Research, Vol. 171, No. 1, 15.07.2006, p. 1-8.

Research output: Contribution to journalArticle

Yang, Mu ; Farrokhi, Catherine ; Vasconcellos, Amy ; Blanchard, Robert J. ; Blanchard, D. Caroline. / Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB). In: Behavioural Brain Research. 2006 ; Vol. 171, No. 1. pp. 1-8.
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