Central galanin administration blocks consolidation of spatial learning

Jefferson W. Kinney, Grzegorz Starosta, Jacqueline Crawley

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Galanin is a neuropeptide that inhibits the evoked release of several neurotransmitters, inhibits the activation of intracellular second messengers, and produces deficits in a variety of rodent learning and memory tasks. To evaluate the actions of galanin on encoding, consolidation, and storage/retrieval, galanin was acutely administered to Sprague-Dawley rats at time points before and after training trials in the Morris water maze. Intraventricular administration of galanin up to 3h after subjects had completed daily training trials in the Morris water task impaired performance on the probe trial, indicating that galanin-blocked consolidation. Pretreatment with an adenylate cyclase activator, forskolin, prevented the deficits in distal cue learning produced by galanin. Di-deoxyforskolin, an inactive analog of forskolin, had no effect. These results provide the first evidence that galanin interferes with long-term memory consolidation processes. A potential mechanism by which galanin produces this impairment may involve the inhibition of adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory.

Original languageEnglish (US)
Pages (from-to)42-54
Number of pages13
JournalNeurobiology of Learning and Memory
Volume80
Issue number1
DOIs
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Galanin
Long-Term Memory
Colforsin
Adenylyl Cyclases
Learning
Spatial Learning
Water
Task Performance and Analysis
Second Messenger Systems
Neuropeptides
Cues
Neurotransmitter Agents
Sprague Dawley Rats
Rodentia

Keywords

  • Adenylate cyclase
  • Alzheimer's disease
  • Consolidation
  • Forskolin
  • Galanin
  • Long-term memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Central galanin administration blocks consolidation of spatial learning. / Kinney, Jefferson W.; Starosta, Grzegorz; Crawley, Jacqueline.

In: Neurobiology of Learning and Memory, Vol. 80, No. 1, 07.2003, p. 42-54.

Research output: Contribution to journalArticle

Kinney, Jefferson W. ; Starosta, Grzegorz ; Crawley, Jacqueline. / Central galanin administration blocks consolidation of spatial learning. In: Neurobiology of Learning and Memory. 2003 ; Vol. 80, No. 1. pp. 42-54.
@article{223f8ce4a2874a90accf8a3561a4438d,
title = "Central galanin administration blocks consolidation of spatial learning",
abstract = "Galanin is a neuropeptide that inhibits the evoked release of several neurotransmitters, inhibits the activation of intracellular second messengers, and produces deficits in a variety of rodent learning and memory tasks. To evaluate the actions of galanin on encoding, consolidation, and storage/retrieval, galanin was acutely administered to Sprague-Dawley rats at time points before and after training trials in the Morris water maze. Intraventricular administration of galanin up to 3h after subjects had completed daily training trials in the Morris water task impaired performance on the probe trial, indicating that galanin-blocked consolidation. Pretreatment with an adenylate cyclase activator, forskolin, prevented the deficits in distal cue learning produced by galanin. Di-deoxyforskolin, an inactive analog of forskolin, had no effect. These results provide the first evidence that galanin interferes with long-term memory consolidation processes. A potential mechanism by which galanin produces this impairment may involve the inhibition of adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory.",
keywords = "Adenylate cyclase, Alzheimer's disease, Consolidation, Forskolin, Galanin, Long-term memory",
author = "Kinney, {Jefferson W.} and Grzegorz Starosta and Jacqueline Crawley",
year = "2003",
month = "7",
doi = "10.1016/S1074-7427(03)00023-6",
language = "English (US)",
volume = "80",
pages = "42--54",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Central galanin administration blocks consolidation of spatial learning

AU - Kinney, Jefferson W.

AU - Starosta, Grzegorz

AU - Crawley, Jacqueline

PY - 2003/7

Y1 - 2003/7

N2 - Galanin is a neuropeptide that inhibits the evoked release of several neurotransmitters, inhibits the activation of intracellular second messengers, and produces deficits in a variety of rodent learning and memory tasks. To evaluate the actions of galanin on encoding, consolidation, and storage/retrieval, galanin was acutely administered to Sprague-Dawley rats at time points before and after training trials in the Morris water maze. Intraventricular administration of galanin up to 3h after subjects had completed daily training trials in the Morris water task impaired performance on the probe trial, indicating that galanin-blocked consolidation. Pretreatment with an adenylate cyclase activator, forskolin, prevented the deficits in distal cue learning produced by galanin. Di-deoxyforskolin, an inactive analog of forskolin, had no effect. These results provide the first evidence that galanin interferes with long-term memory consolidation processes. A potential mechanism by which galanin produces this impairment may involve the inhibition of adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory.

AB - Galanin is a neuropeptide that inhibits the evoked release of several neurotransmitters, inhibits the activation of intracellular second messengers, and produces deficits in a variety of rodent learning and memory tasks. To evaluate the actions of galanin on encoding, consolidation, and storage/retrieval, galanin was acutely administered to Sprague-Dawley rats at time points before and after training trials in the Morris water maze. Intraventricular administration of galanin up to 3h after subjects had completed daily training trials in the Morris water task impaired performance on the probe trial, indicating that galanin-blocked consolidation. Pretreatment with an adenylate cyclase activator, forskolin, prevented the deficits in distal cue learning produced by galanin. Di-deoxyforskolin, an inactive analog of forskolin, had no effect. These results provide the first evidence that galanin interferes with long-term memory consolidation processes. A potential mechanism by which galanin produces this impairment may involve the inhibition of adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory.

KW - Adenylate cyclase

KW - Alzheimer's disease

KW - Consolidation

KW - Forskolin

KW - Galanin

KW - Long-term memory

UR - http://www.scopus.com/inward/record.url?scp=0038299035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038299035&partnerID=8YFLogxK

U2 - 10.1016/S1074-7427(03)00023-6

DO - 10.1016/S1074-7427(03)00023-6

M3 - Article

VL - 80

SP - 42

EP - 54

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 1

ER -