Central anticonvulsant effects of magnesium sulfate on N-methyl-D-aspartate-induced seizures

D. B. Cotton, M. Hallak, C. Janusz, S. M. Irtenkauf, Robert F Berman

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Abstract

Objective: The objective of this study was to determine if magnesium sulfate's central anticonvulsant activity is effective against N-methyl-D-aspartate-induced seizures. Study design: In two separate experiments we investigated magnesium sulfate's ability to inhibit N-methyl-D-aspartate-induced hippocampal seizures in rats. In the first experiment magnesium sulfate was administered peripherally before an intracranial injection of 20 μg of N-methyl-D-aspartate. In the second experiment magnesium sulfate was injected intracranially concurrently with N-methyl-D-aspartate. The ability of magnesium sulfate to suppress N-methyl-D-aspartate-induced seizure activity under both conditions was assessed. Results: Peripherally administered magnesium sulfate significantly increased the latency from the time of an N-methyl-D-aspartate injection to the first seizure both by acute injection and after 2 hours of sustained elevation of serum magnesium levels when compared with saline solution-injected controls (p < 0.01). The duration of the first seizure was also significantly reduced. Intracranially administered magnesium sulfate significantly (p < 0.01) increased the seizure latency period by 120%. Overall, central magnesium sulfate prevented seizure activity in 40% of the animals (p < 0.01). Conclusion: Magnesium sulfate has a central anticonvulsant action on N-methyl-D-aspartate-induced seizures in this rat model of hippocampal seizures.

Original languageEnglish (US)
Pages (from-to)974-978
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume168
Issue number3 I
StatePublished - 1993
Externally publishedYes

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Keywords

  • hippocampus
  • magnesium sulfate
  • N-methyl-D-aspartate (NMDA)
  • seizures

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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