Central and peripheral reservoirs of feline immunodeficiency virus in cats

a review

Chrissy D. Eckstrand, Ellen E. Sparger, Brian G Murphy

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Infection with feline immunodeficiency virus (FIV), a lentivirus similar to human immunodeficiency virus (HIV), results in lifelong viral persistence and progressive immunopathology in the cat. FIV has the ability to infect and produce infectious virus in a number of different cell types. FIV provirus can also be maintained in a replication-competent but transcriptionally quiescent state, facilitating viral persistence over time. Immediately after the initial infection, FIV infection quickly disseminates to many anatomical compartments within the host including lymphoid organs, gastrointestinal tract and brain. Collectively, the anatomic and cellular compartments that harbour FIV provirus constitute the viral reservoir and contain foci of both ongoing viral replication and transcriptionally restricted virus that may persist over time. The relative importance of the different phenotypes observed for infected cells, anatomic compartment, replication status and size of the reservoir represent crucial areas of investigation for developing effective viral suppression and eradication therapies. In this review, we discuss what is currently known about FIV reservoirs, and emphasize the utility of the FIV-infected cat as a model for the HIV-infected human.

Original languageEnglish (US)
Pages (from-to)1985-1996
Number of pages12
JournalThe Journal of general virology
Volume98
Issue number8
DOIs
StatePublished - Aug 1 2017

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Feline Immunodeficiency Virus
Cats
Proviruses
HIV
Viruses
Lentivirus
Virus Diseases
Infection
Gastrointestinal Tract
Cell Count
Phenotype
Brain

ASJC Scopus subject areas

  • Virology

Cite this

Central and peripheral reservoirs of feline immunodeficiency virus in cats : a review. / Eckstrand, Chrissy D.; Sparger, Ellen E.; Murphy, Brian G.

In: The Journal of general virology, Vol. 98, No. 8, 01.08.2017, p. 1985-1996.

Research output: Contribution to journalReview article

Eckstrand, Chrissy D. ; Sparger, Ellen E. ; Murphy, Brian G. / Central and peripheral reservoirs of feline immunodeficiency virus in cats : a review. In: The Journal of general virology. 2017 ; Vol. 98, No. 8. pp. 1985-1996.
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