Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Tianshu Liu, Alan W Shindel, Guiting Lin, Tom F. Lue

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a form of energy transfer that is of lower intensity (<0.2mJ/mm2) relative to traditional Extracorporeal Shock Wave Lithotripsy (ESWL) used for management of urinary stones. At this intensity and at appropriate dosing energy transfer is thought to induce beneficial effects in human tissues. The proposed therapeutic mechanisms of action for Li-ESWT include neovascularization, tissue regeneration, and reduction of inflammation. These effects are thought to be mediated by enhanced expression of vascular endothelial growth factor, endothelial nitric oxide synthase, and proliferating cell nuclear antigen. Upregulation of chemoattractant factors and recruitment/activation of stem/progenitor cells may also play a role. Li-ESWT has been studied for management of musculoskeletal disease, ischemic cardiovascular disorders, Peyronie’s Disease, and more recently erectile dysfunction (ED). The underlying mechanism of Li-ESWT for treatment of ED is incompletely understood. We summarize the current evidence basis by which Li-ESWT is thought to enhance penile hemodynamics with an intention of outlining the fundamental mechanisms by which this therapy may help manage ED.

Original languageEnglish (US)
JournalInternational Journal of Impotence Research
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Fingerprint

Convulsive Therapy
Erectile Dysfunction
Energy Transfer
Stem Cells
Penile Induration
Musculoskeletal Diseases
Urinary Calculi
Lithotripsy
Nitric Oxide Synthase Type III
Chemotactic Factors
Proliferating Cell Nuclear Antigen
Vascular Endothelial Growth Factor A
Regeneration
Up-Regulation
Therapeutics
Hemodynamics
Inflammation

ASJC Scopus subject areas

  • Urology

Cite this

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy. / Liu, Tianshu; Shindel, Alan W; Lin, Guiting; Lue, Tom F.

In: International Journal of Impotence Research, 01.01.2019.

Research output: Contribution to journalArticle

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