Cellular immunity to acetylcholine receptor in myasthenia gravis: Relationship to histocompatibility type and antigenic site

David P Richman, J. P. Antel, J. W. Patrick, B. G W Arnason

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

To determine the nature of the cellular immune response directed against acetylcholine receptor in myasthenia gravis, we compared lymphocyte stimulation by eel receptor with clinical factors. The mean (± SEM) stimulation index was 4.5 ± 0.9 for 39 myasthenic patients and 0.97 ± 0.18 for 48 controls (p < 0.001). Positive response in patients was associated with disease onset after 50 yr (10 of 13 patients) and presence of thymoma (seven of eight patients), but not with HLA type. Stimulation index correlated with disease activity (rs = 0.63, p < 0.01). Blocking the active portion of the receptor molecule with naja toxin resulted in 68% diminution of the response, suggesting that this site plays a significant role in the cellular immune response in myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalNeurology
Volume29
Issue number3
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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