Cellular immune response in primary biliary cirrhosis

Hiroto Kita, Michio Imawari, M. Eric Gershwin

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The generation of immune responsiveness to self-antigen can result in the pathogenic autoimmune damage of tissues mediated by both humoral and cellular immune responses. Primary biliary cirrhosis (PBC) constitutes a model of autoimmune disease reflective of other organ-specific autoimmune feature. Although the etiology of PBC remained elusive, growing data suggest the role of cell-mediated immune response in the pathogenesis of PBC. Indeed, autoreactive CD4 as well as CD8 T cells have been characterized and their epitopes defined. Molecular mimicry is implicated in the initiation of these autoreactive T cell responses. Moreover, selective enrichment of NKT cells in the liver of PBC is demonstrated using CD1d tetramer. In this review, we shall focus on the recent advance of cell-mediated immune responses in PBC, which may be directly associated with inflammatory response in PBC.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalHepatology Research
Volume28
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Cytotoxic T lymphocytes
  • Helper T lymphocytes
  • Mitochondrial autoantigens
  • NKT cells
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

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