Cellular function of protein phosphatase 2C in yeast

K. Shiozaki, P. Russell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Protein phosphatase 2C (PP2C) is one of four major classes of protein serine/threonine-phosphatases, which requires Mg2+ for its activity. PP2C activity distributes ubiquitously among eukaryotes and enzymes purified from mammalian tissues were well characterized biochemically, however, very little is known about their biological function. We have been trying to identify cellular function of PP2C by genetic analyses in fission yeast Schizosaccharomyces pombe. So far, three PP2C homologs, ptc1+, ptc2+, and ptc3+, have been cloned and their activity were detected in the S. pombe cell lysates. Experiments using ptc mutants constructed by gene disruption technique have revealed the involvement of PP2C in the heat shock response and possibly osmoregulation in yeast cells.

Original languageEnglish (US)
Pages (from-to)241-243
Number of pages3
JournalCellular and Molecular Biology Research
Volume40
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Phosphoprotein Phosphatases
Yeast
Yeasts
Schizosaccharomyces
Osmoregulation
Heat-Shock Response
Eukaryota
Protein Phosphatase 2C
Genes
Cells
Tissue
Enzymes
Experiments

Keywords

  • Fission yeast
  • Phosphorylation
  • PP2C
  • Protein phosphatase

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology

Cite this

Cellular function of protein phosphatase 2C in yeast. / Shiozaki, K.; Russell, P.

In: Cellular and Molecular Biology Research, Vol. 40, No. 3, 1994, p. 241-243.

Research output: Contribution to journalArticle

Shiozaki, K & Russell, P 1994, 'Cellular function of protein phosphatase 2C in yeast', Cellular and Molecular Biology Research, vol. 40, no. 3, pp. 241-243.
Shiozaki, K. ; Russell, P. / Cellular function of protein phosphatase 2C in yeast. In: Cellular and Molecular Biology Research. 1994 ; Vol. 40, No. 3. pp. 241-243.
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