Cellular events underlying catecholamine-induced thermogenesis: Cation transport in brown adipocytes

Barbara A Horwitz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Evidence supporting the hypothesis that the active transport of Na+ and K+ contributes significantly to catecholamine-mediated brown fat thermogenesis is reviewed. Such evidence indicates that the Na+/K+ membrane pump is activated following norepinephrine interaction with α- and β-adrenergic membrane receptors. That the involvement of the pump in the thermogenic response is considerable is indicated by the finding that pump inhibition is accompanied by a 50-70% reduction of the catecholamine-evoked respiratory stimulation of isolated hamster brown adipocytes. This inhibitory effect of pump blockade suggests that in the norepinephrine-activated brown adipocyte, the pump generates a stimulatory signal for pathways of substrate oxidation, the operation of these being associated with conversion of chemical energy to heat.

Original languageEnglish (US)
Pages (from-to)2170-2176
Number of pages7
JournalFederation Proceedings
Volume38
Issue number8
StatePublished - 1979

Fingerprint

Brown Adipocytes
Thermogenesis
Catecholamines
Cations
Norepinephrine
Brown Adipose Tissue
Membranes
Active Biological Transport
Cricetinae
Adrenergic Receptors
Signal Transduction
Hot Temperature

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cellular events underlying catecholamine-induced thermogenesis : Cation transport in brown adipocytes. / Horwitz, Barbara A.

In: Federation Proceedings, Vol. 38, No. 8, 1979, p. 2170-2176.

Research output: Contribution to journalArticle

@article{e5339b21a44e4fc2a6d9d4c94d97f37d,
title = "Cellular events underlying catecholamine-induced thermogenesis: Cation transport in brown adipocytes",
abstract = "Evidence supporting the hypothesis that the active transport of Na+ and K+ contributes significantly to catecholamine-mediated brown fat thermogenesis is reviewed. Such evidence indicates that the Na+/K+ membrane pump is activated following norepinephrine interaction with α- and β-adrenergic membrane receptors. That the involvement of the pump in the thermogenic response is considerable is indicated by the finding that pump inhibition is accompanied by a 50-70{\%} reduction of the catecholamine-evoked respiratory stimulation of isolated hamster brown adipocytes. This inhibitory effect of pump blockade suggests that in the norepinephrine-activated brown adipocyte, the pump generates a stimulatory signal for pathways of substrate oxidation, the operation of these being associated with conversion of chemical energy to heat.",
author = "Horwitz, {Barbara A}",
year = "1979",
language = "English (US)",
volume = "38",
pages = "2170--2176",
journal = "Federation Proceedings",
issn = "0014-9446",
number = "8",

}

TY - JOUR

T1 - Cellular events underlying catecholamine-induced thermogenesis

T2 - Cation transport in brown adipocytes

AU - Horwitz, Barbara A

PY - 1979

Y1 - 1979

N2 - Evidence supporting the hypothesis that the active transport of Na+ and K+ contributes significantly to catecholamine-mediated brown fat thermogenesis is reviewed. Such evidence indicates that the Na+/K+ membrane pump is activated following norepinephrine interaction with α- and β-adrenergic membrane receptors. That the involvement of the pump in the thermogenic response is considerable is indicated by the finding that pump inhibition is accompanied by a 50-70% reduction of the catecholamine-evoked respiratory stimulation of isolated hamster brown adipocytes. This inhibitory effect of pump blockade suggests that in the norepinephrine-activated brown adipocyte, the pump generates a stimulatory signal for pathways of substrate oxidation, the operation of these being associated with conversion of chemical energy to heat.

AB - Evidence supporting the hypothesis that the active transport of Na+ and K+ contributes significantly to catecholamine-mediated brown fat thermogenesis is reviewed. Such evidence indicates that the Na+/K+ membrane pump is activated following norepinephrine interaction with α- and β-adrenergic membrane receptors. That the involvement of the pump in the thermogenic response is considerable is indicated by the finding that pump inhibition is accompanied by a 50-70% reduction of the catecholamine-evoked respiratory stimulation of isolated hamster brown adipocytes. This inhibitory effect of pump blockade suggests that in the norepinephrine-activated brown adipocyte, the pump generates a stimulatory signal for pathways of substrate oxidation, the operation of these being associated with conversion of chemical energy to heat.

UR - http://www.scopus.com/inward/record.url?scp=0018757598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018757598&partnerID=8YFLogxK

M3 - Article

C2 - 221273

AN - SCOPUS:0018757598

VL - 38

SP - 2170

EP - 2176

JO - Federation Proceedings

JF - Federation Proceedings

SN - 0014-9446

IS - 8

ER -