Cellular events underlying catecholamine-induced thermogenesis: Cation transport in brown adipocytes

Barbara A Horwitz

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Evidence supporting the hypothesis that the active transport of Na+ and K+ contributes significantly to catecholamine-mediated brown fat thermogenesis is reviewed. Such evidence indicates that the Na+/K+ membrane pump is activated following norepinephrine interaction with α- and β-adrenergic membrane receptors. That the involvement of the pump in the thermogenic response is considerable is indicated by the finding that pump inhibition is accompanied by a 50-70% reduction of the catecholamine-evoked respiratory stimulation of isolated hamster brown adipocytes. This inhibitory effect of pump blockade suggests that in the norepinephrine-activated brown adipocyte, the pump generates a stimulatory signal for pathways of substrate oxidation, the operation of these being associated with conversion of chemical energy to heat.

Original languageEnglish (US)
Pages (from-to)2170-2176
Number of pages7
JournalFederation Proceedings
Volume38
Issue number8
StatePublished - 1979

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Cellular events underlying catecholamine-induced thermogenesis: Cation transport in brown adipocytes'. Together they form a unique fingerprint.

  • Cite this