Evidence supporting the hypothesis that the active transport of Na+ and K+ contributes significantly to catecholamine-mediated brown fat thermogenesis is reviewed. Such evidence indicates that the Na+/K+ membrane pump is activated following norepinephrine interaction with α- and β-adrenergic membrane receptors. That the involvement of the pump in the thermogenic response is considerable is indicated by the finding that pump inhibition is accompanied by a 50-70% reduction of the catecholamine-evoked respiratory stimulation of isolated hamster brown adipocytes. This inhibitory effect of pump blockade suggests that in the norepinephrine-activated brown adipocyte, the pump generates a stimulatory signal for pathways of substrate oxidation, the operation of these being associated with conversion of chemical energy to heat.
|Original language||English (US)|
|Number of pages||7|
|State||Published - 1979|
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