Cellular basis of triggered arrhythmias in heart failure

Steven M. Pogwizd, Donald M Bers

Research output: Contribution to journalArticle

253 Scopus citations

Abstract

Ventricular tachycardia in nonischemic heart failure (HF) initiates by a nonreentrant mechanism that appears to be due to triggered activity primarily from delayed afterdepolarizations that arise from altered cellular Ca handling and ionic currents. In HF, factors that conspire to enhance triggered arrhythmias include upregulated Na/Ca exchange, preserved β-adrenergic responsiveness, and decreased IK1. Overall, the further delineation of key factors that underlie triggered arrhythmias in HF will provide the basis for new therapeutic strategies directed toward novel targets that can reduce the high incidence of sudden death in patients with HF.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume14
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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