Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone with increased susceptibility to fractures in focal sites such as femoral neck and lumbar spine. The current challenge is to optimize treatment for fractures. This article reviews cellular and molecular approaches to osteoporosis. Anabolic signals include growth factors and bone morphogenetic proteins. The responding stem cells of bone marrow stroma are inducible osteoprogenitor cells. The judicious use of local regulators in a focal systemic disease such as osteoporosis presents a formidable challenge. Gene therapy is likely to be an important therapeutic intervention. The integration of physical signals with chemical messengers regulating gene expression of bone cells is a useful future approach.
|Original language||English (US)|
|Number of pages||5|
|Journal||Current Opinion in Orthopaedics|
|State||Published - 1995|
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