Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: Histamine, prostaglandin D2 prostaglandin E2 and leukotriene C4

David G. Baker, Laurel J Gershwin, Shri N. Giri, Congfen Li

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9 Scopus citations

Abstract

Plasma histamine, prostaglandin (PG) D2, PGE2, and leukotriene (LT) C4 levels were determined in 26 Holstein steers before and after natural or experimental infection with Ostertagia ostertagi. Post-infection abomasal lymph was also assayed for PGD2, PGE2, and LTC4. Histamine determinations were performed on abomasal tissue from three locations. Results showed that: (1) tissue histamine levels increased in steers with type 2 ostertagiosis, (2) lymphatic PGD2 and PGE2 levels were increased, probably as a result of macrophage activity, (3) lymphatic LTC4 levels increased in steers with type 1 ostertagiosis, and were correlated with tissue eosinophilia, and (4) plasma levels of PGD2, PGE2, LTC4 and histamine were not useful for predicting worm burdens. These findings suggest a functional role for eosinophils and mast cells in the pathophysiology of ostertagiosis, through mediation of a type 1 hypersensitivity reaction.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalInternational Journal for Parasitology
Volume23
Issue number3
DOIs
StatePublished - 1993

Keywords

  • cattle parasites
  • histamine
  • leukotriene
  • mediators
  • Ostertagia ostertagi
  • prostaglandin

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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