Cellular actions of Al at low (1.25 μM) concentrations in primary oligodendrocyte culture

Mari S. Golub, Wei Zhang, Carl L Keen, Tzipora Goldkorn

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

At a physiologically relevant concentration (1.25 μM), aluminum had an activating effect on oligodendrocyte cell cultures, similar to that previously reported for other cell types. G protein-linked signal transduction was stimulated as indicated by enhanced production of IP3, and protein synthesis was increased. At this concentration Al did not promote cell damage but did enhance oxidative effects initiated by reactive oxygen species. Both AlCl3 and Al transferrin (AlTf) had similar actions at equimolar concentrations. In vivo, physiological Al ion may act by common cellular pathways in diverse cell types. These effects may be relevant to Al toxicological, pharmacological (immunoadjuvant), and physiological effects.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalBrain Research
Volume941
Issue number1-2
DOIs
StatePublished - Jun 21 2002

Keywords

  • Aluminum
  • Cell culture
  • Oligodendrocyte
  • Oxidative damage
  • Protein synthesis
  • Signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)

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