Cell tropism of Salmonella enterica

Renato L. Santos, Andreas J Baumler

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Salmonella serotypes are able to actively cross the intestinal epithelium, mainly but not exclusively through M cells in the follicle-associated epithelium of Peyer's patches. Once reaching the basal side of the epithelium, Salmonella serotypes are internalized by macrophages, dendritic cells, and neutrophils but are not found in fibroblasts or other mesenchymal cells. The outcome of the interaction between Salmonella serotypes and dendritic cells or neutrophils is detrimental to the pathogen. In some host species Salmonella serotypes find a safe haven from humoral defenses and neutrophils within macrophages, and replication within this niche appears to be a prerequisite for the development of a systemic infection. In other host species, macrophages can control bacterial growth and the infection remains localized to the intestine and mesenteric lymph nodes. This review summarizes our knowledge on the cellular tropism of Salmonella serotypes and the bacterial and host factors relevant for these interactions.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalInternational Journal of Medical Microbiology
Issue number4
StatePublished - Oct 2004
Externally publishedYes


  • Dendritic cells
  • Enterocytes
  • M-cells
  • Macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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