Cell Therapy in Parkinson's Disease: Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts

Eleonora Napoli, Cesar V. Borlongan

Research output: Contribution to journalComment/debate

8 Citations (Scopus)

Abstract

This commentary highlights the major findings and future research directions arising from the recent publication by Zuo and colleagues in Stem Cells 2017 (in press). Here, we discuss the novel observations that transplanted human neural stem cells can induce endogenous brain repair by specifically stimulating a host of regenerative processes in the neurogenic niche (i.e., subventricular zone [SVZ]) in an animal model of Parkinson's disease. That the identified therapeutic proteomes, neurotrophic factors, and anti-inflammatory cytokines in the SVZ may facilitate brain regeneration and behavioral recovery open a new venue of research for our understanding of the pathology and treatment of Parkinson's disease. Stem Cells 2017;35:1443–1445.

Original languageEnglish (US)
Pages (from-to)1443-1445
Number of pages3
JournalStem Cells
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Lateral Ventricles
Cell- and Tissue-Based Therapy
Parkinson Disease
Stem Cells
Transplants
Neural Stem Cells
Nerve Growth Factors
Brain
Proteome
Regeneration
Anti-Inflammatory Agents
Animal Models
Pathology
Cytokines
Therapeutics
Research
Direction compound

Keywords

  • Neural stem cells
  • Parkinson's disease
  • Plasticity
  • Transplantation

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Cell Therapy in Parkinson's Disease : Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts. / Napoli, Eleonora; Borlongan, Cesar V.

In: Stem Cells, Vol. 35, No. 6, 01.06.2017, p. 1443-1445.

Research output: Contribution to journalComment/debate

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