Cell polarity: Quantitative modeling as a tool in cell biology

Alex Mogilner, Jun Allard, Roy Wollman

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Among a number of innovative approaches that have modernized cell biology, modeling has a prominent yet unusual place. One popular view is that we progress linearly, from conceptual to ever more detailed models. We review recent discoveries of cell polarity mechanisms, in which modeling played an important role, to demonstrate that the experiment-theory feedback loop requires diverse models characterized by varying levels of biological detail and mathematical complexity. We argue that a quantitative model is a tool that has to fit an experimental study, and the model's value should be judged not by how complex and detailed it is, but by what could be learned from it.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalScience
Volume336
Issue number6078
DOIs
StatePublished - Apr 13 2012

ASJC Scopus subject areas

  • General

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    Mogilner, A., Allard, J., & Wollman, R. (2012). Cell polarity: Quantitative modeling as a tool in cell biology. Science, 336(6078), 175-179. https://doi.org/10.1126/science.1216380