Cell division

Jonathan M. Scholey, Ingrid Brust-Mascher, Alex Mogilner

Research output: Contribution to journalArticle

210 Scopus citations

Abstract

In creating the mitotic spindle and the contractile ring, natural selection has engineered fascinating precision machines whose movements depend upon forces generated by ensembles of cytoskeletal proteins. These machines segregate chromosomes and divide the cell with high fidelity. Current research on the mechanisms and regulation of spindle morphogenesis, chromosome motility and cytokinesis emphasizes how ensembles of dynamic cytoskeletal polymers and multiple motors cooperate to generate the forces that guide the cell through mitosis and cytokinesis.

Original languageEnglish (US)
Pages (from-to)746-752
Number of pages7
JournalNature
Volume422
Issue number6933
DOIs
StatePublished - Apr 17 2003

ASJC Scopus subject areas

  • General

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    Scholey, J. M., Brust-Mascher, I., & Mogilner, A. (2003). Cell division. Nature, 422(6933), 746-752. https://doi.org/10.1038/nature01599