Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Hans Lassmann, Christian Bancher, Helene Breitschopf, Jerzy Wegiel, Matthew Bobinski, Kurt Jellinger, Henryk M. Wisniewski

Research output: Contribution to journalArticlepeer-review

418 Scopus citations


Loss of nerve cells is a hallmark of the pathology of Alzheimer's disease (AD), yet the patterns of cell death are unknown. By analyzing DNA fragmentation in situ we found evidence for cell death not only of nerve cells but also of oligodendrocytes and microglia in AD brains. In average, 30 times more brain cells showed DNA fragmentation in AD as compared to age-matched controls. Nuclear alterations suggestive of apoptosis were rare in degenerating cells. Even though the majority of degenerating cells were not located within amyloid deposits and did not contain neurofibrillary tangles, neurons situated within areas of amyloid deposits or affected by neurofibrillary degeneration revealed a higher risk of DNA fragmentation and death than cells not exposed to these AD changes.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalActa Neuropathologica
Issue number1
StatePublished - Jan 1995
Externally publishedYes


  • β-Amyloid
  • Alzheimer's disease
  • Cell death
  • DNA
  • tragmentation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


Dive into the research topics of 'Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ'. Together they form a unique fingerprint.

Cite this