Abstract
A basic principle of wound healing is that cell loss will also trigger cell regeneration involving proliferation. This simple concept is actually quite difficult to study in the context of the complex multicellular environment of the lung. The pattern of the proliferative response is predicated on the cell type that is damaged, the extent and degree of the damage, and whether the insult is acute or chronic. When studying cell renewal, it is critically important to define the type of damage, its extent, and the cell types involved so that the nature of the reparative response can be put into context. Toxicologists have contributed vital information that has helped define lung cell reparative potential.
| Original language | English (US) |
|---|---|
| Title of host publication | Respiratory Toxicology |
| Publisher | Elsevier Inc. |
| Pages | 223-242 |
| Number of pages | 20 |
| Volume | 8 |
| ISBN (Print) | 9780080468686 |
| DOIs | |
| State | Published - Aug 12 2010 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Cell Damage and Cell Renewal in the Lung. / Van Winkle, L. S.
Respiratory Toxicology. Vol. 8 Elsevier Inc., 2010. p. 223-242.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cell Damage and Cell Renewal in the Lung
AU - Van Winkle, L. S.
PY - 2010/8/12
Y1 - 2010/8/12
N2 - A basic principle of wound healing is that cell loss will also trigger cell regeneration involving proliferation. This simple concept is actually quite difficult to study in the context of the complex multicellular environment of the lung. The pattern of the proliferative response is predicated on the cell type that is damaged, the extent and degree of the damage, and whether the insult is acute or chronic. When studying cell renewal, it is critically important to define the type of damage, its extent, and the cell types involved so that the nature of the reparative response can be put into context. Toxicologists have contributed vital information that has helped define lung cell reparative potential.
AB - A basic principle of wound healing is that cell loss will also trigger cell regeneration involving proliferation. This simple concept is actually quite difficult to study in the context of the complex multicellular environment of the lung. The pattern of the proliferative response is predicated on the cell type that is damaged, the extent and degree of the damage, and whether the insult is acute or chronic. When studying cell renewal, it is critically important to define the type of damage, its extent, and the cell types involved so that the nature of the reparative response can be put into context. Toxicologists have contributed vital information that has helped define lung cell reparative potential.
UR - http://www.scopus.com/inward/record.url?scp=85012821215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012821215&partnerID=8YFLogxK
U2 - 10.1016/B978-0-08-046884-6.00911-8
DO - 10.1016/B978-0-08-046884-6.00911-8
M3 - Chapter
AN - SCOPUS:85012821215
SN - 9780080468686
VL - 8
SP - 223
EP - 242
BT - Respiratory Toxicology
PB - Elsevier Inc.
ER -