Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response

Aris T. Alexandrou, Jian-Jian Li

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Significance: There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated and remains controversial, LDIR is shown to induce temporary but significant adaptive responses in mammalian cells and animals. The mechanisms guiding the mitochondrial function in LDIR-induced adaptive response represent a unique communication between DNA damage and cellular metabolism. Elucidation of the LDIR-regulated mitochondrial activity may reveal new mechanisms adjusting cellular function to cope with hazardous environmental stress. Recent Advances: Key cell cycle regulators, including Cyclin D1/CDK4 and Cyclin B1/cyclin-dependent kinase 1 (CDK1) complexes, are actively involved in the regulation of mitochondrial functions via phosphorylation of their mitochondrial targets. Accumulating new evidence supports a concept that the Cyclin B1/CDK1 complex acts as a mediator in the cross talk between radiation-induced DNA damage and mitochondrial functions to coordinate cellular responses to low-level genotoxic stresses. Critical Issues: The LDIR-mediated mitochondrial activity via Cyclin B1/CDK1 regulation is an irreplaceable network that is able to harmonize vital cellular functions with adjusted mitochondrial metabolism to enhance cellular homeostasis. Future Directions: Further investigation of the coordinative mechanism that regulates mitochondrial activities in sublethal stress conditions, including LDIR, will reveal new insights of how cells cope with genotoxic injury and will be vital for future targeted therapeutic interventions that reduce environmental injury and cancer risk. Antioxid.

Original languageEnglish (US)
Pages (from-to)1463-1480
Number of pages18
JournalAntioxidants and Redox Signaling
Volume20
Issue number9
DOIs
StatePublished - Mar 20 2014

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Ionizing radiation
Ionizing Radiation
Dosimetry
Cell Cycle
Cells
CDC2 Protein Kinase
Radiation
Cyclin B1
DNA Damage
Metabolism
Phosphorylation
Nuclear industry
Health risks
DNA
Cyclin D1
Wounds and Injuries
Atmosphere
Industry
Animals
Homeostasis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response. / Alexandrou, Aris T.; Li, Jian-Jian.

In: Antioxidants and Redox Signaling, Vol. 20, No. 9, 20.03.2014, p. 1463-1480.

Research output: Contribution to journalArticle

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