Cell biology

HST2 mediates SIR2-independent life-span extension by calorie restriction

Dudley W. Lamming, Magda Latorre-Esteves, Oliver Medvedik, Stacy N. Wong, Felicia A. Tsang, Chen Wang, Su Ju Lin, David A. Sinclair

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Calorie restriction (CR) extends the life span of numerous species, from yeast to rodents. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD +)-dependent histone deacetylase that has been proposed to mediate the effects of CR. However, this hypothesis has been challenged by the observation that CR can extend yeast life span in the absence of Sir2. Here, we show that Sir2-independent life-span extension is mediated by Hst2, a Sir2 homolog that promotes the stability of repetitive ribosomal DNA, the same mechanism by which Sir2 extends life span. These findings demonstrate that the maintenance of DNA stability is critical for yeast life-span extension by CR and suggest that, in higher organisms, multiple members of the Sir2 family may regulate life span in response to diet.

Original languageEnglish (US)
Pages (from-to)1861-1864
Number of pages4
JournalScience
Volume309
Issue number5742
DOIs
StatePublished - Sep 16 2005

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Life Expectancy
Cell Biology
Yeasts
NAD
Histone Deacetylases
Ribosomal DNA
Rodentia
Maintenance
Diet
DNA

ASJC Scopus subject areas

  • General

Cite this

Lamming, D. W., Latorre-Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., ... Sinclair, D. A. (2005). Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction. Science, 309(5742), 1861-1864. https://doi.org/10.1126/science.1113611

Cell biology : HST2 mediates SIR2-independent life-span extension by calorie restriction. / Lamming, Dudley W.; Latorre-Esteves, Magda; Medvedik, Oliver; Wong, Stacy N.; Tsang, Felicia A.; Wang, Chen; Lin, Su Ju; Sinclair, David A.

In: Science, Vol. 309, No. 5742, 16.09.2005, p. 1861-1864.

Research output: Contribution to journalArticle

Lamming, DW, Latorre-Esteves, M, Medvedik, O, Wong, SN, Tsang, FA, Wang, C, Lin, SJ & Sinclair, DA 2005, 'Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction', Science, vol. 309, no. 5742, pp. 1861-1864. https://doi.org/10.1126/science.1113611
Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C et al. Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction. Science. 2005 Sep 16;309(5742):1861-1864. https://doi.org/10.1126/science.1113611
Lamming, Dudley W. ; Latorre-Esteves, Magda ; Medvedik, Oliver ; Wong, Stacy N. ; Tsang, Felicia A. ; Wang, Chen ; Lin, Su Ju ; Sinclair, David A. / Cell biology : HST2 mediates SIR2-independent life-span extension by calorie restriction. In: Science. 2005 ; Vol. 309, No. 5742. pp. 1861-1864.
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