Cell biology and biochemistry of endochondral bone development

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363 Scopus citations


The differentiation of mesenchymal cells to bone can occur by one of two routes. First, there is a direct development of bone from mesenchyme, as in the skull, which is referred to as intramembranous ossification. Second, an intervening cartilage model precedes the formation of bone from mesenchymal cells; and this occurs in the long bones and is known as endochondral bone formation. It has been emphasized that these two modes of ossification connote only the environment in which bone formation occurs and, they do not significantly differ in the kind of bone formed. The aim of this review is to describe recent progress in the realm of the cell biology and biochemistry of endochondral bone development. It is our intention to provide only a selective survey of the area, and no attempt has been made to be comprehensive.

Original languageEnglish (US)
Pages (from-to)209-226
Number of pages18
JournalCollagen and Related Research
Issue number2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology


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