Abstract
The differentiation of mesenchymal cells to bone can occur by one of two routes. First, there is a direct development of bone from mesenchyme, as in the skull, which is referred to as intramembranous ossification. Second, an intervening cartilage model precedes the formation of bone from mesenchymal cells; and this occurs in the long bones and is known as endochondral bone formation. It has been emphasized that these two modes of ossification connote only the environment in which bone formation occurs and, they do not significantly differ in the kind of bone formed. The aim of this review is to describe recent progress in the realm of the cell biology and biochemistry of endochondral bone development. It is our intention to provide only a selective survey of the area, and no attempt has been made to be comprehensive.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 209-226 |
| Number of pages | 18 |
| Journal | Collagen and Related Research |
| Volume | 1 |
| Issue number | 2 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Rheumatology
Cite this
Cell biology and biochemistry of endochondral bone development. / Reddi, A Hari.
In: Collagen and Related Research, Vol. 1, No. 2, 1981, p. 209-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell biology and biochemistry of endochondral bone development
AU - Reddi, A Hari
PY - 1981
Y1 - 1981
N2 - The differentiation of mesenchymal cells to bone can occur by one of two routes. First, there is a direct development of bone from mesenchyme, as in the skull, which is referred to as intramembranous ossification. Second, an intervening cartilage model precedes the formation of bone from mesenchymal cells; and this occurs in the long bones and is known as endochondral bone formation. It has been emphasized that these two modes of ossification connote only the environment in which bone formation occurs and, they do not significantly differ in the kind of bone formed. The aim of this review is to describe recent progress in the realm of the cell biology and biochemistry of endochondral bone development. It is our intention to provide only a selective survey of the area, and no attempt has been made to be comprehensive.
AB - The differentiation of mesenchymal cells to bone can occur by one of two routes. First, there is a direct development of bone from mesenchyme, as in the skull, which is referred to as intramembranous ossification. Second, an intervening cartilage model precedes the formation of bone from mesenchymal cells; and this occurs in the long bones and is known as endochondral bone formation. It has been emphasized that these two modes of ossification connote only the environment in which bone formation occurs and, they do not significantly differ in the kind of bone formed. The aim of this review is to describe recent progress in the realm of the cell biology and biochemistry of endochondral bone development. It is our intention to provide only a selective survey of the area, and no attempt has been made to be comprehensive.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019500534&partnerID=8YFLogxK
M3 - Article
VL - 1
SP - 209
EP - 226
JO - Matrix Biology
JF - Matrix Biology
SN - 0945-053X
IS - 2
ER -