Cell behavior on lithographically defined nanostructured substrates

Ana I. Teixeira; George A. Abrams; Christopher J Murphy; Paul F. Nealey

Cell behavior on lithographically defined nanostructured substrates

Ana I. Teixeira, George A. Abrams, Christopher J Murphy, Paul F. Nealey

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of substrate topography on the behavior of human corneal epithelial cells was investigated using substrates patterned with grooves and ridges. It was found that cells responded to topographic features as small as 70 nm wide by aligning with the pattern direction. Results showed that substrate topography affected internal organization of the cell, inducing the alignment of cytoskeletal elements and adhesives structures.

Original language	English (US)
Pages (from-to)	683-687
Number of pages	5
Journal	Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Volume	21
Issue number	2
State	Published - Mar 2003
Externally published	Yes

ASJC Scopus subject areas

Electrical and Electronic Engineering
Physics and Astronomy (miscellaneous)
Surfaces and Interfaces

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title = "Cell behavior on lithographically defined nanostructured substrates",

abstract = "The effects of substrate topography on the behavior of human corneal epithelial cells was investigated using substrates patterned with grooves and ridges. It was found that cells responded to topographic features as small as 70 nm wide by aligning with the pattern direction. Results showed that substrate topography affected internal organization of the cell, inducing the alignment of cytoskeletal elements and adhesives structures.",

author = "Teixeira, {Ana I.} and Abrams, {George A.} and Murphy, {Christopher J} and Nealey, {Paul F.}",

year = "2003",

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language = "English (US)",

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AU - Abrams, George A.

AU - Murphy, Christopher J

AU - Nealey, Paul F.

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N2 - The effects of substrate topography on the behavior of human corneal epithelial cells was investigated using substrates patterned with grooves and ridges. It was found that cells responded to topographic features as small as 70 nm wide by aligning with the pattern direction. Results showed that substrate topography affected internal organization of the cell, inducing the alignment of cytoskeletal elements and adhesives structures.

AB - The effects of substrate topography on the behavior of human corneal epithelial cells was investigated using substrates patterned with grooves and ridges. It was found that cells responded to topographic features as small as 70 nm wide by aligning with the pattern direction. Results showed that substrate topography affected internal organization of the cell, inducing the alignment of cytoskeletal elements and adhesives structures.

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Cell behavior on lithographically defined nanostructured substrates

Abstract

ASJC Scopus subject areas

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