Cell behavior on lithographically defined nanostructured substrates

Ana I. Teixeira, George A. Abrams, Christopher J Murphy, Paul F. Nealey

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The effects of substrate topography on the behavior of human corneal epithelial cells was investigated using substrates patterned with grooves and ridges. It was found that cells responded to topographic features as small as 70 nm wide by aligning with the pattern direction. Results showed that substrate topography affected internal organization of the cell, inducing the alignment of cytoskeletal elements and adhesives structures.

Original languageEnglish (US)
Pages (from-to)683-687
Number of pages5
JournalJournal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Issue number2
StatePublished - Mar 2003
Externally publishedYes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Physics and Astronomy (miscellaneous)
  • Surfaces and Interfaces


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