CD97 is a multifunctional leukocyte receptor with distinct roles in human cancers (Review)

Michael Safaee, Aaron J. Clark, Michael E. Ivan, Michael C. Oh, Orin Bloch, Matthew Z. Sun, Taemin Oh, Andrew T. Parsa

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


G-protein coupled receptors (GPCRs) represent the most diverse and biologically ubiquitous protein receptors. The epidermal growth factor seven-span transmembrane (EGF-TM7) family consists of adhesion GPCRs with a diverse functional repertoire. CD97 is the most broadly expressed member with roles in cell adhesion, migration and regulation of intercellular junctions. CD97 is also expressed in a variety of human malignancies including those of the thyroid, stomach, colon and brain. CD97 confers an invasive phenotype and has been shown to correlate with tumor grade, lymph node invasion, metastatic spread and overall prognosis. More recently, CD97 was found to signal through Gα12/13, resulting in increased RHO-GTP levels. Proven roles in tumor invasion and signaling make CD97 an exciting novel therapeutic target. In this review, we will discuss the structure and function of this receptor, with a specific focus on its mechanistic significance in neoplastic diseases.

Original languageEnglish (US)
Pages (from-to)1343-1350
Number of pages8
JournalInternational journal of oncology
Issue number5
StatePublished - Nov 1 2013
Externally publishedYes


  • Cancer
  • CD97
  • EGF-TM7
  • Invasion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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