CD8+-Cell-Mediated Suppression of Virulent Simian Immunodeficiency Virus during Tenofovir Treatment

Koen K.A. Van Rompay, Raman P. Singh, Bapi Pahar, Donald L. Sodora, Casey Wingfield, Jonathan R. Lawson, Marta Marthas, Norbert Bischofberger

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The ability of tenofovir to suppress viremia in simian immunodeficiency virus (SIV)-infected macaques for years despite the presence of virulent viral mutants with reduced in vitro susceptibility is unprecedented in this animal model. In vivo cell depletion experiments demonstrate that tenofovir's ability to suppress viremia during acute and chronic infection is significantly dependent on the presence of CD8+ lymphocytes. Continuous tenofovir treatment was required to maintain low viremia. Although it is unclear whether this immune-mediated suppression of viremia is linked to tenofovir's direct antiviral efficacy or is due to independent immunomodulatory effects, these studies prove the concept that antiviral immune responses can play a crucial role in suppressing viremia during anti-human immunodeficiency virus drug therapy.

Original languageEnglish (US)
Pages (from-to)5324-5337
Number of pages14
JournalJournal of Virology
Volume78
Issue number10
DOIs
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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