CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation

Chin Pan, Nicole Baumgarth, Jane R. Parnes

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

CD72, a B cell surface protein of the C-type lectin superfamily, recruits the tyrosine phosphatase SHP-1 through its ITIM motif(s). Using CD72-deficient (CD72(-/-)) mice, we demonstrate that CD72 is a nonredundant regulator of B cell development. In the bone marrow of CD72(-/-) mice, there was a reduction in the number of mature recirculating B cells and an accumulation of pre-B cells. In the periphery of CD72(-/-) mice, there were fewer mature B-2 cells and more B-1 cells. In addition, CD72 is a negative regulator of B cell activation, as CD72(-/-) B cells were hyperproliferative in response to various stimuli and showed enhanced kinetics in their intracellular Ca2+ response following IgM cross-linking.

Original languageEnglish (US)
Pages (from-to)495-506
Number of pages12
JournalImmunity
Volume11
Issue number4
DOIs
StatePublished - Oct 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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