TY - JOUR
T1 - CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation
AU - Pan, Chin
AU - Baumgarth, Nicole
AU - Parnes, Jane R.
PY - 1999/10
Y1 - 1999/10
N2 - CD72, a B cell surface protein of the C-type lectin superfamily, recruits the tyrosine phosphatase SHP-1 through its ITIM motif(s). Using CD72-deficient (CD72(-/-)) mice, we demonstrate that CD72 is a nonredundant regulator of B cell development. In the bone marrow of CD72(-/-) mice, there was a reduction in the number of mature recirculating B cells and an accumulation of pre-B cells. In the periphery of CD72(-/-) mice, there were fewer mature B-2 cells and more B-1 cells. In addition, CD72 is a negative regulator of B cell activation, as CD72(-/-) B cells were hyperproliferative in response to various stimuli and showed enhanced kinetics in their intracellular Ca2+ response following IgM cross-linking.
AB - CD72, a B cell surface protein of the C-type lectin superfamily, recruits the tyrosine phosphatase SHP-1 through its ITIM motif(s). Using CD72-deficient (CD72(-/-)) mice, we demonstrate that CD72 is a nonredundant regulator of B cell development. In the bone marrow of CD72(-/-) mice, there was a reduction in the number of mature recirculating B cells and an accumulation of pre-B cells. In the periphery of CD72(-/-) mice, there were fewer mature B-2 cells and more B-1 cells. In addition, CD72 is a negative regulator of B cell activation, as CD72(-/-) B cells were hyperproliferative in response to various stimuli and showed enhanced kinetics in their intracellular Ca2+ response following IgM cross-linking.
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U2 - 10.1016/S1074-7613(00)80124-7
DO - 10.1016/S1074-7613(00)80124-7
M3 - Article
C2 - 10549631
AN - SCOPUS:0033212751
VL - 11
SP - 495
EP - 506
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 4
ER -