Abstract
We demonstrate that adoptive transfer of peritoneal cavity B cells fails to replenish the peripheral B-1 cells in adult B cell-deficient (μ(-/-)) mice but does replenish adult RAG-1(-/-) mice. We show that this lack of self-replenishment in μ(-/-) mice is mediated by strongly inhibitory, radiation-sensitive CD4+ T cells that also function in cotransfer studies to block the reconstitution of B-1 cells and inhibit accumulation of bone marrow-derived B-2 cells in the periphery in irradiated recipients. CD8+ T cells from μ(-/-) do not mediate this inhibition. The inhibitory CD4+ T cells develop early in life, because B-1 cell replenishment occurs normally when B-1 cells are transferred into μ(-/-) neonates. Thus, we conclude that the presence of B cells in the neonate conditions the CD4+ T-cell population to permit the establishment and maintenance of normal B cell pools throughout life.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4766-4771 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 97 |
| Issue number | 9 |
| DOIs | |
| State | Published - Apr 25 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
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CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. / Baumgarth, Nicole; Jager, Gina C.; Herman, Ometa C.; Herzenberg, Leonard A.; Herzenberg, Leonore A.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 9, 25.04.2000, p. 4766-4771.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools
AU - Baumgarth, Nicole
AU - Jager, Gina C.
AU - Herman, Ometa C.
AU - Herzenberg, Leonard A.
AU - Herzenberg, Leonore A.
PY - 2000/4/25
Y1 - 2000/4/25
N2 - We demonstrate that adoptive transfer of peritoneal cavity B cells fails to replenish the peripheral B-1 cells in adult B cell-deficient (μ(-/-)) mice but does replenish adult RAG-1(-/-) mice. We show that this lack of self-replenishment in μ(-/-) mice is mediated by strongly inhibitory, radiation-sensitive CD4+ T cells that also function in cotransfer studies to block the reconstitution of B-1 cells and inhibit accumulation of bone marrow-derived B-2 cells in the periphery in irradiated recipients. CD8+ T cells from μ(-/-) do not mediate this inhibition. The inhibitory CD4+ T cells develop early in life, because B-1 cell replenishment occurs normally when B-1 cells are transferred into μ(-/-) neonates. Thus, we conclude that the presence of B cells in the neonate conditions the CD4+ T-cell population to permit the establishment and maintenance of normal B cell pools throughout life.
AB - We demonstrate that adoptive transfer of peritoneal cavity B cells fails to replenish the peripheral B-1 cells in adult B cell-deficient (μ(-/-)) mice but does replenish adult RAG-1(-/-) mice. We show that this lack of self-replenishment in μ(-/-) mice is mediated by strongly inhibitory, radiation-sensitive CD4+ T cells that also function in cotransfer studies to block the reconstitution of B-1 cells and inhibit accumulation of bone marrow-derived B-2 cells in the periphery in irradiated recipients. CD8+ T cells from μ(-/-) do not mediate this inhibition. The inhibitory CD4+ T cells develop early in life, because B-1 cell replenishment occurs normally when B-1 cells are transferred into μ(-/-) neonates. Thus, we conclude that the presence of B cells in the neonate conditions the CD4+ T-cell population to permit the establishment and maintenance of normal B cell pools throughout life.
UR - http://www.scopus.com/inward/record.url?scp=0034712736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034712736&partnerID=8YFLogxK
U2 - 10.1073/pnas.97.9.4766
DO - 10.1073/pnas.97.9.4766
M3 - Article
C2 - 10781082
AN - SCOPUS:0034712736
VL - 97
SP - 4766
EP - 4771
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 9
ER -