CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools

Nicole Baumgarth, Gina C. Jager, Ometa C. Herman, Leonard A. Herzenberg, Leonore A. Herzenberg

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

We demonstrate that adoptive transfer of peritoneal cavity B cells fails to replenish the peripheral B-1 cells in adult B cell-deficient (μ(-/-)) mice but does replenish adult RAG-1(-/-) mice. We show that this lack of self-replenishment in μ(-/-) mice is mediated by strongly inhibitory, radiation-sensitive CD4+ T cells that also function in cotransfer studies to block the reconstitution of B-1 cells and inhibit accumulation of bone marrow-derived B-2 cells in the periphery in irradiated recipients. CD8+ T cells from μ(-/-) do not mediate this inhibition. The inhibitory CD4+ T cells develop early in life, because B-1 cell replenishment occurs normally when B-1 cells are transferred into μ(-/-) neonates. Thus, we conclude that the presence of B cells in the neonate conditions the CD4+ T-cell population to permit the establishment and maintenance of normal B cell pools throughout life.

Original languageEnglish (US)
Pages (from-to)4766-4771
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number9
DOIs
StatePublished - Apr 25 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • General

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