CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection

Suefen Kwa, Shanmugalakshmi Sadagopal, Xiaoying Shen, Jung Joo Hong, Sailaja Gangadhara, Rahul Basu, Blandine Victor, Smita Iyer, Celia C. LaBranche, David C. Montefiori, Georgia D. Tomaras, Francois Villinger, Bernard Moss, Pamela A. Kozlowski, Rama Rao Amara

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.

Original languageEnglish (US)
Pages (from-to)4690-4695
Number of pages6
JournalJournal of Virology
Volume89
Issue number8
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Kwa, S., Sadagopal, S., Shen, X., Hong, J. J., Gangadhara, S., Basu, R., Victor, B., Iyer, S., LaBranche, C. C., Montefiori, D. C., Tomaras, G. D., Villinger, F., Moss, B., Kozlowski, P. A., & Amara, R. R. (2015). CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. Journal of Virology, 89(8), 4690-4695. https://doi.org/10.1128/JVI.03527-14