CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection

Suefen Kwa, Shanmugalakshmi Sadagopal, Xiaoying Shen, Jung Joo Hong, Sailaja Gangadhara, Rahul Basu, Blandine Victor, Smita Iyer, Celia C. LaBranche, David C. Montefiori, Georgia D. Tomaras, Francois Villinger, Bernard Moss, Pamela A. Kozlowski, Rama Rao Amara

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.

Original languageEnglish (US)
Pages (from-to)4690-4695
Number of pages6
JournalJournal of Virology
Volume89
Issue number8
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Vaccinia virus
CD40 Ligand
Virus Diseases
neutralization
Vaccines
vaccines
DNA
infection
Immunodominant Epitopes
epitopes
Antiviral Agents
Epitopes
Acquired Immunodeficiency Syndrome
digestive system
T-lymphocytes
Immunoglobulin G
peptides
T-Lymphocytes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. / Kwa, Suefen; Sadagopal, Shanmugalakshmi; Shen, Xiaoying; Hong, Jung Joo; Gangadhara, Sailaja; Basu, Rahul; Victor, Blandine; Iyer, Smita; LaBranche, Celia C.; Montefiori, David C.; Tomaras, Georgia D.; Villinger, Francois; Moss, Bernard; Kozlowski, Pamela A.; Amara, Rama Rao.

In: Journal of Virology, Vol. 89, No. 8, 01.01.2015, p. 4690-4695.

Research output: Contribution to journalArticle

Kwa, S, Sadagopal, S, Shen, X, Hong, JJ, Gangadhara, S, Basu, R, Victor, B, Iyer, S, LaBranche, CC, Montefiori, DC, Tomaras, GD, Villinger, F, Moss, B, Kozlowski, PA & Amara, RR 2015, 'CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection', Journal of Virology, vol. 89, no. 8, pp. 4690-4695. https://doi.org/10.1128/JVI.03527-14
Kwa, Suefen ; Sadagopal, Shanmugalakshmi ; Shen, Xiaoying ; Hong, Jung Joo ; Gangadhara, Sailaja ; Basu, Rahul ; Victor, Blandine ; Iyer, Smita ; LaBranche, Celia C. ; Montefiori, David C. ; Tomaras, Georgia D. ; Villinger, Francois ; Moss, Bernard ; Kozlowski, Pamela A. ; Amara, Rama Rao. / CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. In: Journal of Virology. 2015 ; Vol. 89, No. 8. pp. 4690-4695.
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