CD34: To select or not to select? That is the question

M. A. Dao, Jan Nolta

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34+ cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalLeukemia
Volume14
Issue number5
StatePublished - 2000
Externally publishedYes

Keywords

  • CD34
  • Hematopoietic stem cells
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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