CD34: To select or not to select? That is the question

M. A. Dao, Jan Nolta

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34+ cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalLeukemia
Volume14
Issue number5
StatePublished - 2000
Externally publishedYes

Fingerprint

Stem Cells
Population
Cell Separation
Stem Cell Transplantation
Cell Lineage
Hematopoietic Stem Cells
Uncertainty
Blood Cells
Cell Membrane

Keywords

  • CD34
  • Hematopoietic stem cells
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

CD34 : To select or not to select? That is the question. / Dao, M. A.; Nolta, Jan.

In: Leukemia, Vol. 14, No. 5, 2000, p. 773-776.

Research output: Contribution to journalArticle

Dao, M. A. ; Nolta, Jan. / CD34 : To select or not to select? That is the question. In: Leukemia. 2000 ; Vol. 14, No. 5. pp. 773-776.
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