CD34: To select or not to select? That is the question

M. A. Dao, Jan Nolta

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34+ cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalLeukemia
Volume14
Issue number5
StatePublished - 2000
Externally publishedYes

Keywords

  • CD34
  • Hematopoietic stem cells
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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