CD34-reactive trichodiscoma

Molly Chartier, Michael L. Reed, Srinivas Mandavilli, Maxwell A Fung, Jane M. Grant-Kels, Michael Murphy

Research output: Contribution to journalArticle

9 Scopus citations


Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. Case report: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34 + dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.

Original languageEnglish (US)
Pages (from-to)398-400
Number of pages3
JournalJournal of Cutaneous Pathology
Issue number5
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

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    Chartier, M., Reed, M. L., Mandavilli, S., Fung, M. A., Grant-Kels, J. M., & Murphy, M. (2004). CD34-reactive trichodiscoma. Journal of Cutaneous Pathology, 31(5), 398-400.