Abstract
Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. Case report: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34 + dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 398-400 |
| Number of pages | 3 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
Cite this
CD34-reactive trichodiscoma. / Chartier, Molly; Reed, Michael L.; Mandavilli, Srinivas; Fung, Maxwell A; Grant-Kels, Jane M.; Murphy, Michael.
In: Journal of Cutaneous Pathology, Vol. 31, No. 5, 05.2004, p. 398-400.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD34-reactive trichodiscoma
AU - Chartier, Molly
AU - Reed, Michael L.
AU - Mandavilli, Srinivas
AU - Fung, Maxwell A
AU - Grant-Kels, Jane M.
AU - Murphy, Michael
PY - 2004/5
Y1 - 2004/5
N2 - Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. Case report: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34 + dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.
AB - Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. Case report: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34 + dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.
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UR - http://www.scopus.com/inward/citedby.url?scp=1942532325&partnerID=8YFLogxK
U2 - 10.1111/j.0303-6987.2004.00202.x
DO - 10.1111/j.0303-6987.2004.00202.x
M3 - Article
C2 - 15059227
AN - SCOPUS:1942532325
VL - 31
SP - 398
EP - 400
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 5
ER -