CD34-reactive trichodiscoma

Molly Chartier, Michael L. Reed, Srinivas Mandavilli, Maxwell A Fung, Jane M. Grant-Kels, Michael Murphy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. Case report: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. Results: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. Conclusions: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34 + dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.

Original languageEnglish (US)
Pages (from-to)398-400
Number of pages3
JournalJournal of Cutaneous Pathology
Volume31
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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Cellular Structures
Skin
MART-1 Antigen
Factor XIIIa
Inheritance Patterns
Desmin
Hamartoma
Intermediate Filaments
Mesoderm
Nose
Hair
Differential Diagnosis
Extremities
Immunohistochemistry
Cell Proliferation

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Chartier, M., Reed, M. L., Mandavilli, S., Fung, M. A., Grant-Kels, J. M., & Murphy, M. (2004). CD34-reactive trichodiscoma. Journal of Cutaneous Pathology, 31(5), 398-400. https://doi.org/10.1111/j.0303-6987.2004.00202.x

CD34-reactive trichodiscoma. / Chartier, Molly; Reed, Michael L.; Mandavilli, Srinivas; Fung, Maxwell A; Grant-Kels, Jane M.; Murphy, Michael.

In: Journal of Cutaneous Pathology, Vol. 31, No. 5, 05.2004, p. 398-400.

Research output: Contribution to journalArticle

Chartier, M, Reed, ML, Mandavilli, S, Fung, MA, Grant-Kels, JM & Murphy, M 2004, 'CD34-reactive trichodiscoma', Journal of Cutaneous Pathology, vol. 31, no. 5, pp. 398-400. https://doi.org/10.1111/j.0303-6987.2004.00202.x
Chartier M, Reed ML, Mandavilli S, Fung MA, Grant-Kels JM, Murphy M. CD34-reactive trichodiscoma. Journal of Cutaneous Pathology. 2004 May;31(5):398-400. https://doi.org/10.1111/j.0303-6987.2004.00202.x
Chartier, Molly ; Reed, Michael L. ; Mandavilli, Srinivas ; Fung, Maxwell A ; Grant-Kels, Jane M. ; Murphy, Michael. / CD34-reactive trichodiscoma. In: Journal of Cutaneous Pathology. 2004 ; Vol. 31, No. 5. pp. 398-400.
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