CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor

Shinichi Sato, Joseph Tuscano, Makoto Inaoki, Thomas F. Tedder

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

The CD22 cell-surface adhesion molecule is capable of modulating B B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector, proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic, changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation.

Original languageEnglish (US)
Pages (from-to)287-297
Number of pages11
JournalSeminars in Immunology
Volume10
Issue number4
DOIs
StatePublished - Aug 1998

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Keywords

  • B lymphocyte
  • CD22
  • CD22-deficient mice
  • SHP1
  • Signal transduction
  • Vav

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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