Abstract
The CD22 cell-surface adhesion molecule is capable of modulating B B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector, proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic, changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 287-297 |
| Number of pages | 11 |
| Journal | Seminars in Immunology |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1998 |
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Keywords
- B lymphocyte
- CD22
- CD22-deficient mice
- SHP1
- Signal transduction
- Vav
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. / Sato, Shinichi; Tuscano, Joseph; Inaoki, Makoto; Tedder, Thomas F.
In: Seminars in Immunology, Vol. 10, No. 4, 08.1998, p. 287-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor
AU - Sato, Shinichi
AU - Tuscano, Joseph
AU - Inaoki, Makoto
AU - Tedder, Thomas F.
PY - 1998/8
Y1 - 1998/8
N2 - The CD22 cell-surface adhesion molecule is capable of modulating B B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector, proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic, changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation.
AB - The CD22 cell-surface adhesion molecule is capable of modulating B B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector, proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic, changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation.
KW - B lymphocyte
KW - CD22
KW - CD22-deficient mice
KW - SHP1
KW - Signal transduction
KW - Vav
UR - http://www.scopus.com/inward/record.url?scp=0032147065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032147065&partnerID=8YFLogxK
U2 - 10.1006/smim.1998.0121
DO - 10.1006/smim.1998.0121
M3 - Article
C2 - 9695185
AN - SCOPUS:0032147065
VL - 10
SP - 287
EP - 297
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
IS - 4
ER -