CD22, A B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling

Thomas F. Tedder, Joseph Tuscano, Shinichi Sato, John H. Kehrl

Research output: Contribution to journalArticle

247 Scopus citations

Abstract

The development of B lymphocytes is a highly regulated process that depends in part on lineage-specific cell surface molecules. In addition, transmembrane signals generated through the B cell antigen receptor and other surface molecules regulate B cell responses to foreign antigens. Recent studies reveal CD22 to be a functionally significant receptor during these processes. CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 is a member of the lg superfamily that serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and allleukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. CD22 signaling is mediated via interactions with a number of kinases and phosphatases that bind the cytoplasmic domain through phosphorylated tyrosine residues located within consensus TAM and TIM motifs. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. Most notable in CD22-deficient mice is a significant diminution of surface Ig levels in these B cell subpopulations, which suggests that CD22 functions in vivo to adjust the signaling threshold of cell surface antigen receptors. A further understanding of CD22 function is required and may reveal roles for CD22 in disease susceptibility or the development of autoimmunity.

Original languageEnglish (US)
Pages (from-to)481-504
Number of pages24
JournalAnnual Review of Immunology
Volume15
DOIs
StatePublished - 1997
Externally publishedYes

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Keywords

  • B lymphocyte
  • differentiation antigen
  • immunoglobulin
  • intercellular adhesion
  • signal transduction

ASJC Scopus subject areas

  • Immunology

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