CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma

Xiangdong Xu, Elizabeth H. Broome, Hooman Rashidi, Sarah T. South, Marie L. Dell'Aquila, Huan You Wang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We report a CD20dim- positive T-cell large granular lymphocytic (T-LGL) leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. This patient was first diagnosed with T-LGL leukemia with dim CD20 expression, which by itself was a rare entity. He received no treatment for T-LGL leukemia. The patient later developed a hairy cell leukemia, which went into complete clinical remission after one cycle of 2-CdA. Five years later, he was diagnosed with a third malignancy, plasma cell myeloma. Complex cytogenetic aberrancies were present at the time when plasma cell myeloma was diagnosed. This is the first report, to the best of our knowledge, in the English literature with the aforementioned three distinct hematopoietic malignancies in one patient.

Original languageEnglish (US)
Pages (from-to)798-807
Number of pages10
JournalInternational Journal of Clinical and Experimental Pathology
Volume3
Issue number8
StatePublished - Dec 1 2010

Keywords

  • Cd20
  • Hairy cell leukemia
  • Plasma cell myeloma
  • T-cell large granular lymphocytic leukemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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